Wang Ping, Wu Xiaoqian, Bao Yingxia, Fang Jian, Zhou Sigui, Gao Jie, Pi Rongbiao, Mou Yong-Gao, Liu Peiqing
Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.
Pharmazie. 2011 Jul;66(7):517-24.
Tanshinone IIA is one of major constituents of Salvia miltiorrhiza Bunge known as Danshen. Our and others' studies have shown that Tan IIA could protect cardimyocyte against apoptosis; however the effect of Tan IIA on cardiac remodeling disease is still unknown. In this study, we investigated the effects of Tan IIA on cardiac hypertrophy and fibrosis in two-kidney, two-clip (2K2C) hypertensive rats and by which, if any, mechanisms. Administration of 2K2C hypertensive rats with Tan IIA attenuated cardiac dysfunction and fibrosis. However Tan IIA treatment had no effects on BP control. Further studies revealed that Tan IIA inhibited the increased NAD(P)H oxidase activity and expression as well as O2*- production in 2K2C hypertensive rats. Our results indicated that Tan IIA significantly improved cardiac function and attenuated fibrosis in 2K2C hypertensive rats. The protective action of Tan IIA is likely mediated by its antioxidant effect, independent of BP control, partially via inhibiting NADPH oxidase.
丹参酮IIA是丹参（学名：Salvia miltiorrhiza Bunge）的主要成分之一。我们和其他人的研究表明，丹参酮IIA可以保护心肌细胞免于凋亡；然而，丹参酮IIA对心脏重塑疾病的影响仍然未知。在本研究中，我们研究了丹参酮IIA对两肾两夹（2K2C）高血压大鼠心脏肥大和纤维化的影响及其作用机制（如果存在的话）。给2K2C高血压大鼠施用丹参酮IIA可减轻心脏功能障碍和纤维化。然而，丹参酮IIA治疗对血压控制没有影响。进一步的研究表明，丹参酮IIA抑制2K2C高血压大鼠中NAD(P)H氧化酶活性、表达以及O2*生成的增加。我们的结果表明，丹参酮IIA显著改善了2K2C高血压大鼠的心脏功能并减轻了纤维化。丹参酮IIA的保护作用可能是由其抗氧化作用介导的，与血压控制无关，部分是通过抑制NADPH氧化酶实现的。
