Biology Department and Center for Natural Sciences and Ecological Research, De La Salle University, 2401 Taft Avenue, Manila 1004, Philippines.
Z Naturforsch C J Biosci. 2011 May-Jun;66(5-6):235-44. doi: 10.1515/znc-2011-5-606.
Cycloartenyl stearate (1a), lupenyl stearate (1b), sitosteryl stearate (1c), and 24-methylenecycloartanyl stearate (1d) (sample 1) from the air-dried leaves of Syzygium samarangense exhibited potent analgesic and anti-inflammatory activities at effective doses of 6.25 mg/kg body weight and 12.5 mg/kg body weight, respectively. Sample 1 also exhibited negligible toxicity on zebrafish embryonic tissues. There were incidences of mortality upon direct exposure of sample 1 to dechorionated embryos, but higher mortality and aberration were observed during intact chorion treatment.
从山竹子（Syzygium samarangense）的干燥叶片中分离得到的环阿屯醇硬脂酸酯（1a）、羽扇豆醇硬脂酸酯（1b）、谷甾醇硬脂酸酯（1c）和 24-亚甲基环阿屯醇硬脂酸酯（1d）（样品 1）在有效剂量为 6.25mg/kg 体重和 12.5mg/kg 体重时分别表现出较强的镇痛和抗炎活性。样品 1 对斑马鱼胚胎组织也表现出很小的毒性。当样品 1 直接暴露于脱壳胚胎时，有死亡率发生，但在完整卵壳处理时观察到更高的死亡率和畸形。
