膜扰动引发依赖于 IRF3 的、干扰素非依赖的抗病毒反应。
Membrane perturbation elicits an IRF3-dependent, interferon-independent antiviral response.
机构信息
Department of Biochemistry and Biomedical Sciences, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.
出版信息
J Virol. 2011 Oct;85(20):10926-31. doi: 10.1128/JVI.00862-11. Epub 2011 Aug 3.
Abstract
We previously found that enveloped virus binding and penetration are necessary to initiate an interferon-independent, IRF3-mediated antiviral response. To investigate whether membrane perturbations that accompany membrane fusion-dependent enveloped-virus entry are necessary and sufficient for antiviral-state induction, we utilized a reovirus fusion-associated small transmembrane (FAST) protein. Membrane disturbances during FAST protein-mediated fusion, in the absence of additional innate immune response triggers, are sufficient to elicit interferon-stimulated gene induction and establishment of an antiviral state. Using sensors of membrane disruption to activate an IRF3-dependent, interferon-independent antiviral state may provide cells with a rapid, broad-spectrum innate immune response to enveloped-virus infections.
摘要
我们之前发现，包膜病毒的结合和穿透对于启动干扰素非依赖性、IRF3 介导的抗病毒反应是必要的。为了研究伴随膜融合依赖性包膜病毒进入的膜扰动是否对于诱导抗病毒状态是必要和充分的，我们利用了呼肠孤病毒融合相关的小跨膜（FAST）蛋白。在没有其他先天免疫反应触发的情况下，FAST 蛋白介导的融合过程中的膜干扰足以引发干扰素刺激基因的诱导和抗病毒状态的建立。利用膜破坏的传感器激活 IRF3 依赖性、干扰素非依赖性抗病毒状态可能为细胞提供对包膜病毒感染的快速、广谱的先天免疫反应。
相似文献
1
Membrane perturbation elicits an IRF3-dependent, interferon-independent antiviral response.
J Virol. 2011 Oct;85(20):10926-31. doi: 10.1128/JVI.00862-11. Epub 2011 Aug 3.
2
Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation.
J Virol. 2018 Apr 13;92(9). doi: 10.1128/JVI.01947-17. Print 2018 May 1.
3
Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry.
J Virol. 2015 Dec 30;90(6):3018-27. doi: 10.1128/JVI.02642-15.
4
Differential modification of interferon regulatory factor 3 following virus particle entry.
J Virol. 2009 May;83(9):4013-22. doi: 10.1128/JVI.02069-08. Epub 2009 Feb 11.
5
Innate cellular response to virus particle entry requires IRF3 but not virus replication.
J Virol. 2004 Feb;78(4):1706-17. doi: 10.1128/jvi.78.4.1706-1717.2004.
6
C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response.
J Biol Chem. 2018 Jul 6;293(27):10561-10573. doi: 10.1074/jbc.RA117.001491. Epub 2018 May 25.
7
Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3.
Viruses. 2020 May 31;12(6):599. doi: 10.3390/v12060599.
8
Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense.
PLoS Pathog. 2017 Oct 30;13(10):e1006713. doi: 10.1371/journal.ppat.1006713. eCollection 2017 Oct.
9
Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction.
J Biol Chem. 2017 Oct 6;292(40):16722-16733. doi: 10.1074/jbc.M117.805127. Epub 2017 Aug 28.
10
Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent.
J Biol Chem. 2010 Feb 26;285(9):6080-90. doi: 10.1074/jbc.M109.054486. Epub 2010 Jan 4.
引用本文的文献
1
Virus replication is not required for oncolytic bovine herpesvirus-1 immunotherapy.
Mol Ther Oncol. 2024 Nov 18;32(4):200906. doi: 10.1016/j.omton.2024.200906. eCollection 2024 Dec 19.
2
Differential Cellular Sensing of Fusion from within and Fusion from without during Virus Infection.
Viruses. 2023 Jan 21;15(2):301. doi: 10.3390/v15020301.
3
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy.
Signal Transduct Target Ther. 2022 Dec 23;7(1):394. doi: 10.1038/s41392-022-01252-z.
4
Host Restriction Factors Modulating HIV Latency and Replication in Macrophages.
Int J Mol Sci. 2022 Mar 11;23(6):3021. doi: 10.3390/ijms23063021.
5
Type I Interferon-Mediated Regulation of Antiviral Capabilities of Neutrophils.
Int J Mol Sci. 2021 Apr 29;22(9):4726. doi: 10.3390/ijms22094726.
6
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.
iScience. 2021 May 21;24(5):102477. doi: 10.1016/j.isci.2021.102477. Epub 2021 Apr 26.
7
Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection.
iScience. 2020 Nov 27;23(12):101864. doi: 10.1016/j.isci.2020.101864. eCollection 2020 Dec 18.
8
Cell type- and replication stage-specific influenza virus responses in vivo.
PLoS Pathog. 2020 Aug 13;16(8):e1008760. doi: 10.1371/journal.ppat.1008760. eCollection 2020 Aug.
9
Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection.
iScience. 2020 Mar 27;23(3):100958. doi: 10.1016/j.isci.2020.100958. Epub 2020 Mar 2.
10
Sensor Sensibility-HIV-1 and the Innate Immune Response.
Cells. 2020 Jan 20;9(1):254. doi: 10.3390/cells9010254.
本文引用的文献
1
IFI16 is an innate immune sensor for intracellular DNA.
Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3.
2
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
Nat Immunol. 2010 Jun;11(6):487-94. doi: 10.1038/ni.1876. Epub 2010 May 9.
3
Sensing and signaling in antiviral innate immunity.
Curr Biol. 2010 Apr 13;20(7):R328-33. doi: 10.1016/j.cub.2010.01.044.
4
Recognition of viral nucleic acids in innate immunity.
Rev Med Virol. 2010 Jan;20(1):4-22. doi: 10.1002/rmv.633.
5
Different activities of the reovirus FAST proteins and influenza hemagglutinin in cell-cell fusion assays and in response to membrane curvature agents.
Virology. 2010 Feb 5;397(1):119-29. doi: 10.1016/j.virol.2009.10.039. Epub 2009 Nov 20.
6
Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN.
J Immunol. 2009 Nov 15;183(10):6545-53. doi: 10.4049/jimmunol.0900867. Epub 2009 Oct 28.
7
Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.
PLoS Pathog. 2009 Oct;5(10):e1000607. doi: 10.1371/journal.ppat.1000607. Epub 2009 Oct 2.
8
NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens.
Semin Immunol. 2009 Aug;21(4):199-207. doi: 10.1016/j.smim.2009.05.007. Epub 2009 Jun 17.
9
Cell fusion-induced activation of interferon-stimulated genes is not required for restriction of a herpes simplex virus VP16/ICP0 mutant in heterokarya formed between permissive and restrictive cells.
J Virol. 2009 Sep;83(17):8976-9. doi: 10.1128/JVI.00142-09. Epub 2009 Jun 17.
10
Infection with herpes simplex type 1-based amplicon vectors results in an IRF3/7-dependent, TLR-independent activation of the innate antiviral response in primary human fibroblasts.
J Gen Virol. 2009 Sep;90(Pt 9):2209-20. doi: 10.1099/vir.0.012203-0. Epub 2009 Jun 10.
Zotero 插件