Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Hong Kong Med J. 2011 Aug;17(4):267-73.
To compare the urinary symptoms and quality of life in ex-ketamine abusers and controls.
Prospective observational study.
A hospital in Hong Kong.
Female ex-ketamine abusers admitted to a local drug rehabilitation centre and age-matched controls attending a general gynaecology clinic between December 2009 and April 2010.
Evaluation of urinary symptoms based on a 3-day bladder diary, and responses to the Urogenital Distress Inventory Short Form (UDI-6) and the Incontinence Impact Questionnaire Short Form (IIQ-7). The study group had repeat measurements 3 months later.
Overall, 90% of ex-ketamine abusers had active urinary symptoms. On average, they had increased 24-hour urinary frequency (10.0 vs 5.8; P=0.001) and lower maximum voided volume (253.3 mL vs 401.9 mL; P<0.001) compared to controls. Correspondingly, the median functional bladder capacity was smaller (195.3 mL vs 261.2 mL; P=0.011) and the mean UDI-6 and IIQ-7 scores were higher (P<0.001). Among those who abused ketamine for 2 years or more, the mean UDI-6 and IIQ-7 scores were higher (P=0.03, P=0.02 respectively). When they stopped abusing ketamine for 3 months or more, their mean 24-hour urinary frequency had decreased (P=0.03), the maximum voided volume had increased (P=0.03) and the mean UDI-6 and IIQ-7 scores had decreased (P=0.04, P=0.02 respectively), although they were still higher than in controls. After 3 more months, in the ex-ketamine abusers there had been a further decrease in 24-hour urinary frequency (P=0.01) and a further improvement in quality of life based on mean UDI-6 scores (P=0.04) but nevertheless poorer than the control group (P<0.01).
Female ex-ketamine abusers had significant urinary symptoms affecting their quality of life when studied at a mean of 8 (range, 0.5-48) months after cessation of use. The symptom severity was inversely correlated with the duration of cessation; though they improved with time, some still persisted.
比较氯胺酮滥用者和对照组的尿症状和生活质量。
前瞻性观察研究。
香港一家医院。
2009 年 12 月至 2010 年 4 月期间，被收治于当地戒毒中心的女性氯胺酮滥用者和在普通妇科诊所就诊的年龄匹配的对照组。
根据 3 天膀胱日记评估尿症状，以及对尿生殖窘迫量表（UDI-6）和尿失禁影响问卷短表（IIQ-7）的反应。研究组在 3 个月后进行了重复测量。
总体而言，90%的氯胺酮滥用者有活跃的尿症状。与对照组相比，他们的平均 24 小时排尿频率增加（10.0 比 5.8；P=0.001），最大排尿量减少（253.3 毫升比 401.9 毫升；P<0.001）。相应地，中位功能性膀胱容量更小（195.3 毫升比 261.2 毫升；P=0.011），UDI-6 和 IIQ-7 的平均评分更高（P<0.001）。在滥用氯胺酮 2 年或以上的人群中，UDI-6 和 IIQ-7 的平均评分更高（P=0.03，P=0.02）。当他们停止滥用氯胺酮 3 个月或以上时，他们的平均 24 小时排尿频率下降（P=0.03），最大排尿量增加（P=0.03），UDI-6 和 IIQ-7 的平均评分下降（P=0.04，P=0.02），尽管仍高于对照组。3 个月后，在氯胺酮滥用者中，24 小时排尿频率进一步下降（P=0.01），基于 UDI-6 评分的生活质量进一步改善（P=0.04），但仍差于对照组（P<0.01）。
在停止使用氯胺酮平均 8（范围 0.5-48）个月后进行研究时，女性氯胺酮滥用者的尿症状明显影响其生活质量。症状严重程度与停止使用的时间呈反比；尽管随着时间的推移有所改善，但有些仍持续存在。
