Wang Dan, Han Ling, Guo Zengjun
Faculty of Pharmacy, Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
Nat Prod Commun. 2011 Jun;6(6):799-802.
Agents with phase II enzyme inducing activities play important roles in intervening in the carcinogenic process. In the present study, the quinone reductase (QR) inducing activities of nine known triterpene saponins from the dichloromethane/ethanol extract of the roots of Pulsatilla chinensis were tested. The oleanane saponins exhibited more potent QR inducing activities than the lupane saponins, and the CD value of the compound with the most potent QR inducing activity was 1.1 microM. The chemopreventive activity of the dichloromethane/ethanol extract was also evaluated using the DMBA-induced mice model.
具有Ⅱ相酶诱导活性的物质在干预致癌过程中发挥着重要作用。在本研究中，对从白头翁根的二氯甲烷/乙醇提取物中得到的9种已知三萜皂苷的醌还原酶（QR）诱导活性进行了测试。齐墩果烷型皂苷表现出比羽扇豆烷型皂苷更强的QR诱导活性，且具有最强QR诱导活性的化合物的CD值为1.1微摩尔。还使用二甲基苯并蒽诱导的小鼠模型评估了二氯甲烷/乙醇提取物的化学预防活性。
