Lecomte F, Thauvin-Eliopoulos C, Le Boete I, Grise G, Lemeland J F
Service des Maladies Infectieuses, CHU de Rouen, France.
Scand J Infect Dis. 1990;22(1):75-8. doi: 10.3109/00365549009023122.
The ciprofloxacin efficacy was compared to that of tobramycin in an Escherichia coli pyelonephritis model in rat. Treatments started 48 h after ligation of the left ureter and inoculation of the bladder and continued for 5 days. Ciprofloxacin (2.5 mg/kg/d and 10 mg/kg/d) was administered intravenously either in a single daily dose or in 2 divided doses at 12 h intervals. Tobramycin (2.5 mg/kg/d and 10 mg/kg/d) was administered by the intramuscular route, in a single daily dose. Ciprofloxacin 10 mg/kg/d was as efficacious as tobramycin irrespective of dosage schedule. Ciprofloxacin 2.5 mg/kg/d was more effective when given twice a day than once.
在大鼠大肠杆菌肾盂肾炎模型中，将环丙沙星的疗效与妥布霉素进行了比较。在结扎左输尿管并接种膀胱48小时后开始治疗，持续5天。环丙沙星（2.5毫克/千克/天和10毫克/千克/天）以每日单次剂量或每12小时间隔分两次静脉给药。妥布霉素（2.5毫克/千克/天和10毫克/千克/天）通过肌肉注射途径每日单次给药。无论给药方案如何，环丙沙星10毫克/千克/天与妥布霉素疗效相当。环丙沙星2.5毫克/千克/天每日给药两次比每日给药一次更有效。
