肠道 CD103+树突状细胞：耐受的主要调节者？

Intestinal CD103+ dendritic cells: master regulators of tolerance?

机构信息

Institute of Infection, Immunology and Inflammation, Sir Graeme Davies Building, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.

出版信息

Trends Immunol. 2011 Sep;32(9):412-9. doi: 10.1016/j.it.2011.06.003. Epub 2011 Aug 2.

DOI:10.1016/j.it.2011.06.003

PMID:21816673

Abstract

CD103(+) dendritic cells (DCs) in the intestinal mucosa play a crucial role in tolerance to commensal bacteria and food antigens. These cells originate in the lamina propria (LP) and migrate to the mesenteric lymph nodes (MLNs), where they drive the differentiation of gut-homing FoxP3(+) regulatory T cells by producing retinoic acid from dietary vitamin A. Local 'conditioning' factors in the LP might also contribute to this tolerogenic profile of CD103(+) DCs. Considerably less is understood about the generation of active immunity or inflammation in the intestinal mucosa. This might require alterations in pre-existing CD103(+) DCs, arrival of new DCs, or the action of a distinct DC population. Here, we discuss our current knowledge of this as yet incompletely understood population.

摘要

肠道黏膜中的 CD103(+)树突状细胞 (DCs) 在耐受共生细菌和食物抗原方面发挥着关键作用。这些细胞起源于固有层 (LP)，并迁移到肠系膜淋巴结 (MLNs)，在那里它们通过从膳食维生素 A 中产生视黄酸来驱动肠道归巢的 FoxP3(+)调节性 T 细胞的分化。LP 中的局部“调节”因子也可能有助于 CD103(+) DCs 的这种耐受表型。对于肠道黏膜中主动免疫或炎症的产生，人们的了解要少得多。这可能需要改变现有 CD103(+) DCs 的特性、新的 DCs 的出现，或者是一个独特的 DC 群体的作用。在这里，我们讨论了我们目前对这一尚未完全了解的群体的认识。