Zemel P C, Zemel M B, Urberg M, Douglas F L, Geiser R, Sowers J R
Division of Endocrinology, Nutrition and Hypertension, Wayne State University, School of Medicine, Detroit, MI.
Am J Clin Nutr. 1990 Apr;51(4):665-9. doi: 10.1093/ajcn/51.4.665.
The effect of magnesium supplementation on blood pressure, erythrocyte cation metabolism, and serum lipids was evaluated in 13 patients with mild hypertension. After randomization and a 3-wk placebo run-in period, seven patients received 40 mmol Mg aspartate (20 mmol elemental Mg twice daily) and six received placebo for 3 mo. In comparison with placebo treatment, magnesium aspartate therapy had no effect on blood pressure, lipid concentrations, or erythrocyte cation metabolism. These results demonstrate that in magnesium-repleted hypertensive subjects, magnesium supplementation does not affect blood pressure or lipids probably because magnesium has no effect on cellular cation metabolism in magnesium-replete individuals.
对13例轻度高血压患者评估了补充镁对血压、红细胞阳离子代谢及血脂的影响。随机分组并经过3周的安慰剂导入期后，7例患者接受40 mmol门冬氨酸镁（每日2次，每次20 mmol元素镁），6例患者接受安慰剂，为期3个月。与安慰剂治疗相比，门冬氨酸镁治疗对血压、血脂浓度或红细胞阳离子代谢无影响。这些结果表明，在镁充足的高血压患者中，补充镁不影响血压或血脂，可能是因为镁对镁充足个体的细胞阳离子代谢无影响。
