Department of Psychogeriatrics, Clinical Science, Division of Clinical Chemistry, Lund University Hospital, S-22185 Lund, Sweden.
Clin Biochem. 2011 Oct;44(14-15):1205-8. doi: 10.1016/j.clinbiochem.2011.07.011. Epub 2011 Jul 27.
Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness.
We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time.
Patients with AD showed overall lower CRP levels than other patients with mental illness, but elevated CRP levels in these patients were associated with lower cognitive function and shorter survival time.
The reason for an overall low CRP level is not obvious. Elevated CRP level in patients with AD suggests the presence of inflammatory activity in this subgroup of patients that may benefit from anti-inflammatory administration.
先前的研究观察到，与对照组或其他伴有精神疾病的老年患者的诊断组相比，确诊的阿尔茨海默病（AD）患者的血清 CRP 水平降低。
我们研究了 CRP 水平与 AD 严重程度之间的关系，该严重程度通过认知功能、脑成像和生存时间来评估。
AD 患者的 CRP 水平总体低于其他伴有精神疾病的患者，但这些患者的 CRP 水平升高与认知功能降低和生存时间缩短有关。
CRP 水平总体较低的原因尚不清楚。AD 患者 CRP 水平升高表明该亚组患者存在炎症活动，可能受益于抗炎治疗。
