Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Torun, Poland.
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 1;879(25):2542-8. doi: 10.1016/j.jchromb.2011.07.007. Epub 2011 Jul 18.
The polypyrrole (PPy) and polythiophene (PTh) solid phase microextraction (SPME) coatings were obtained with the use of the electropolymerisation and linear sweep voltammetry. Such fibers were modified by an ozone treatment in a gaseous phase in the concentration of 2.1 ± 0.2 × 10(-5) mol dm(-3). Both kinds of fibers were applied in the microextraction of linezolid from standard solutions to compare the extraction efficiencies displayed by these sorption phases. In these investigations a better adsorption capacity was obtained for polypyrrole fibers and hence only these kinds of fibers were utilized in the measurements from human plasma. In all measurements the concentrations of the drugs were in the range from 1 to 20 μg ml(-1) (standard solutions) and 1 to 15 μg ml(-1) (human plasma). Before the measurements, an optimization of the desorption solution experiments was performed. The correlation coefficients (R) obtained in the standard solution and human plasma were in the range from 0.8399 to 0.9970. The relative standard deviations (RSDs) were in the range of 0.1-7.6%.
聚吡咯（PPy）和聚噻吩（PTh）固相微萃取（SPME）涂层是通过使用电化学聚合和线性扫描伏安法获得的。这些纤维通过在气相中用浓度为 2.1±0.2×10(-5)mol dm(-3)的臭氧进行处理来进行修饰。两种纤维都被应用于从标准溶液中萃取利奈唑胺，以比较这些吸附相表现出的萃取效率。在这些研究中，聚吡咯纤维具有更好的吸附能力，因此仅使用这些纤维进行了来自人血浆的测量。在所有测量中，药物的浓度范围为 1 至 20μgml(-1)（标准溶液）和 1 至 15μgml(-1)（人血浆）。在测量之前，对解吸溶液实验进行了优化。在标准溶液和人血浆中获得的相关系数（R）范围为 0.8399 至 0.9970。相对标准偏差（RSD）范围为 0.1-7.6%。
