Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Torun, Poland.
Anal Bioanal Chem. 2011 Sep;401(4):1377-84. doi: 10.1007/s00216-011-5159-0. Epub 2011 Jun 28.
A novel sorbent in solid phase microextraction (SPME) method based on poly(3-alkylthiophenes) was used in the isolation of linezolid from human plasma samples following liquid chromatography determination. The effect of extraction time on the sorption capacity of the SPME process was studied and pointed at 10 min both for adsorption and desorption. Poly(3-methylthiophene) and poly(3-nonylthiophene) were applied for the extraction of linezolid from water solutions. In plasma samples, four coatings including polythiophene and poly(3-penthylthiophene) were investigated. With these measurements, correlation coefficients were calculated in the range from 0.9820 to 0.9995, and the relative standard deviations were below 15%. That allowed claiming that the synthesized and described materials can be successfully applied in the analysis of linezolid also from other matrices such as urine or blood.
一种基于聚（3-烷基噻吩）的固相微萃取（SPME）方法中的新型吸附剂，用于在液相色谱测定后从人血浆样品中分离利奈唑胺。研究了萃取时间对 SPME 过程吸附容量的影响，结果表明吸附和解析时间均为 10 分钟。聚（3-甲基噻吩）和聚（3-壬基噻吩）用于从水溶液中萃取利奈唑胺。在血浆样品中，研究了包括聚噻吩和聚（3-戊基噻吩）在内的四种涂层。通过这些测量，计算了相关系数在 0.9820 到 0.9995 之间，相对标准偏差低于 15%。这表明合成和描述的材料可以成功地应用于利奈唑胺的分析，也可以应用于尿液或血液等其他基质。
