Oslo Sports Trauma Research Center and Department of Orthopedic Surgery, Akershus University Hospital, Lørenskog, N-1478 Lørenskog, Norway.
Br Med Bull. 2011;99:227-40. doi: 10.1093/bmb/ldr032. Epub 2011 Aug 5.
Stem cells are easily accessible and have great potential for healing articular cartilage defects. These features make stem cell therapy an appealing approach for treating severely impaired joint function.
Clinical and basic research articles and literature reviews.
Stem cells possess the potential to build articular cartilage. Malalignment and instability corrections and proper rehabilitation are crucial prerequisites for surgical procedures involving stem cell therapy. Smoking reduces the result.
Ethical concerns remain unresolved. No standards are established for inducing stem cell potential, optimizing culturing media or harvesting. The risk of failure has not been determined.
Surgical scaffolds can improve results. Care givers should focus on re-educating patients. Improved funding is needed for developing the therapy.
Define guidelines for stem cell therapy and demonstrate effectiveness.
干细胞易于获取，在修复关节软骨缺损方面具有巨大的潜力。这些特点使干细胞治疗成为治疗严重关节功能障碍的一种有吸引力的方法。
临床和基础研究文章以及文献综述。
干细胞具有构建关节软骨的潜力。矫正对线不良和不稳定以及适当的康复是涉及干细胞治疗的手术程序的关键前提条件。吸烟会降低治疗效果。
伦理问题仍未解决。诱导干细胞潜能、优化培养介质或收获方面尚无标准。失败的风险尚未确定。
外科支架可以改善治疗效果。护理人员应注重重新教育患者。需要为开发这种疗法提供更多资金。
制定干细胞治疗指南并证明其有效性。
