Newton Ede Matthew P, Khan Wasim
Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK.
J Stem Cells. 2010;5(4):167-75.
Articular cartilage injuries pose a treatment challenge. These injuries are a direct cause of pain and loss of function and may precipitate osteoarthritis in the affected joint. Typically affecting a younger, more active population whose expectations of treatment and need for long term joint preservation are high. Articular cartilage poses a treatment challenge in that its capacity for satisfactory healing is limited. The common endpoint of conservative management and traditional surgical interventions is the generation of biomechanically inferior fibrocartilage. Regenerative techniques using human stem cells would appear to represent an exciting modality for the production of true hyaline cartilage with material and biological properties suited for lasting function. This review article summarises the current research regarding the use of human stem cells in the treatment of such injuries.
关节软骨损伤带来了治疗挑战。这些损伤是疼痛和功能丧失的直接原因，可能会促使受影响关节发生骨关节炎。通常影响较年轻、活动较多的人群，他们对治疗的期望以及长期保留关节的需求都很高。关节软骨带来治疗挑战的原因在于其实现满意愈合的能力有限。保守治疗和传统手术干预的常见结局是产生生物力学性能较差的纤维软骨。使用人类干细胞的再生技术似乎是一种令人兴奋的方式，可产生具有适合持久功能的材料和生物学特性的真正透明软骨。这篇综述文章总结了目前关于使用人类干细胞治疗此类损伤的研究。
