动物双歧杆菌亚种。乳源纤溶酶原结合活性在人类胃肠道微环境中的相关性。
Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment.
机构信息
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro n.6, Bologna, Italy.
出版信息
Appl Environ Microbiol. 2011 Oct;77(19):7072-6. doi: 10.1128/AEM.00413-11. Epub 2011 Aug 5.
Abstract
Human plasmin(ogen) is regarded as a component of the molecular cross talk between the probiotic species Bifidobacterium animalis subsp. lactis and the human host. However, up to now, only in vitro studies have been reported. Here, we demonstrate that the probiotic strain B. animalis subsp. lactis BI07 is capable of recruiting plasmin(ogen) present at physiological concentrations in crude extracts from human feces. Our results provide evidence that supports the significance of the B. lactis-plasmin(ogen) interaction in the human gastrointestinal tract.
摘要
人纤溶酶原（ogen）被认为是益生菌双歧杆菌亚种。乳双歧亚种和人类宿主之间分子串扰的一个组成部分。然而，到目前为止，只有体外研究报告。在这里，我们证明了益生菌菌株 B. 动物亚种。乳双歧杆菌 BI07 能够招募纤溶酶原（ogen）存在于生理浓度在从人粪便粗提物中。我们的研究结果为双歧杆菌-纤溶酶原（ogen）相互作用在人类胃肠道中的重要性提供了证据。
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