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本文引用的文献

1
The extracellular proteome of Bifidobacterium animalis subsp. lactis BB-12 reveals proteins with putative roles in probiotic effects.动物双歧杆菌亚种乳双歧杆菌 BB-12 的细胞外蛋白质组揭示了具有益生菌作用的潜在功能的蛋白质。
Proteomics. 2011 Jun;11(12):2503-14. doi: 10.1002/pmic.201000716. Epub 2011 May 20.
2
To be or not to be a pathogen: that is the mucosally relevant question.生存还是毁灭：这是黏膜相关的问题。
Mucosal Immunol. 2011 Jan;4(1):8-14. doi: 10.1038/mi.2010.77. Epub 2010 Dec 8.
3
Genomic insights into bifidobacteria.双歧杆菌的基因组研究进展
Microbiol Mol Biol Rev. 2010 Sep;74(3):378-416. doi: 10.1128/MMBR.00004-10.
4
Oxalate-degrading activity in Bifidobacterium animalis subsp. lactis: impact of acidic conditions on the transcriptional levels of the oxalyl coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes.嗜酸乳杆菌亚种乳杆菌中草酸降解活性：酸性条件对草酰辅酶 A（CoA）脱羧酶和甲酰辅酶 A 转移酶基因转录水平的影响。
Appl Environ Microbiol. 2010 Aug;76(16):5609-20. doi: 10.1128/AEM.00844-10. Epub 2010 Jul 2.
5
DnaK from Bifidobacterium animalis subsp. lactis is a surface-exposed human plasminogen receptor upregulated in response to bile salts.乳双歧杆菌亚种 DnaK 是一种表面暴露的人纤溶酶原受体，对胆盐有应答性地上调。
Microbiology (Reading). 2010 Jun;156(Pt 6):1609-1618. doi: 10.1099/mic.0.038307-0. Epub 2010 Feb 18.
6
Murine fecal proteomics: a model system for the detection of potential biomarkers for colorectal cancer.鼠类粪便蛋白质组学：用于检测结直肠癌潜在生物标志物的模型系统。
J Chromatogr A. 2010 May 7;1217(19):3330-40. doi: 10.1016/j.chroma.2009.10.007. Epub 2009 Oct 8.
7
Comparison of the complete genome sequences of Bifidobacterium animalis subsp. lactis DSM 10140 and Bl-04.动物双歧杆菌乳亚种DSM 10140与Bl-04全基因组序列的比较。
J Bacteriol. 2009 Jul;191(13):4144-51. doi: 10.1128/JB.00155-09. Epub 2009 Apr 17.
8
Exploring the diversity of the bifidobacterial population in the human intestinal tract.探索人类肠道中双歧杆菌种群的多样性。
Appl Environ Microbiol. 2009 Mar;75(6):1534-45. doi: 10.1128/AEM.02216-08. Epub 2009 Jan 23.
9
Shotgun metaproteomics of the human distal gut microbiota.人类远端肠道微生物群的鸟枪法宏蛋白质组学
ISME J. 2009 Feb;3(2):179-89. doi: 10.1038/ismej.2008.108. Epub 2008 Oct 30.
10
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.结肠中两层依赖Muc2粘蛋白的黏液层的内层没有细菌。
Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9. doi: 10.1073/pnas.0803124105. Epub 2008 Sep 19.

动物双歧杆菌亚种。乳源纤溶酶原结合活性在人类胃肠道微环境中的相关性。

Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment.

机构信息

Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro n.6, Bologna, Italy.

出版信息

Appl Environ Microbiol. 2011 Oct;77(19):7072-6. doi: 10.1128/AEM.00413-11. Epub 2011 Aug 5.

DOI:10.1128/AEM.00413-11
PMID:21821753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3187096/
Abstract

Human plasmin(ogen) is regarded as a component of the molecular cross talk between the probiotic species Bifidobacterium animalis subsp. lactis and the human host. However, up to now, only in vitro studies have been reported. Here, we demonstrate that the probiotic strain B. animalis subsp. lactis BI07 is capable of recruiting plasmin(ogen) present at physiological concentrations in crude extracts from human feces. Our results provide evidence that supports the significance of the B. lactis-plasmin(ogen) interaction in the human gastrointestinal tract.

摘要

人纤溶酶原（ogen）被认为是益生菌双歧杆菌亚种。乳双歧亚种和人类宿主之间分子串扰的一个组成部分。然而，到目前为止，只有体外研究报告。在这里，我们证明了益生菌菌株 B. 动物亚种。乳双歧杆菌 BI07 能够招募纤溶酶原（ogen）存在于生理浓度在从人粪便粗提物中。我们的研究结果为双歧杆菌-纤溶酶原（ogen）相互作用在人类胃肠道中的重要性提供了证据。