动物双歧杆菌乳亚种KLDS 2.0603的全基因组序列，这是一种具有消化道抗性且能黏附于肠上皮细胞的益生菌菌株。
Complete genome sequence of Bifidobacterium animalis subsp. lactis KLDS 2.0603, a probiotic strain with digestive tract resistance and adhesion to the intestinal epithelial cells.
作者信息
Zhu Dequan, Sun Yu, Huo Gui-Cheng, Yang Limei, Liu Fei, Li Aili, Meng Xiang-Chen
机构信息
Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, People's Republic of China; Synergetic Innovation Center of Food Safety and Nutrition, Northeast Agricultural University, Harbin 150030, People's Republic of China; College of Life Sciences, Jiamusi University, Jiamusi 154007, People's Republic of China.
Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin 150030, People's Republic of China; Synergetic Innovation Center of Food Safety and Nutrition, Northeast Agricultural University, Harbin 150030, People's Republic of China.
出版信息
J Biotechnol. 2016 Feb 20;220:49-50. doi: 10.1016/j.jbiotec.2016.01.013. Epub 2016 Jan 18.
Bifidobacterium animalis subsp. lactis KLDS 2.0603 (abbreviated as KLDS 2.0603) is a probiotic strain isolated from the feces of an adult human. Previous studies showed that KLDS 2.0603 has a high resistance to simulated digestive tract conditions and a high ability to adhere to intestinal epithelial cells (Caco-2). These two characteristics are essential requirements for the selection of probiotic bacteria. To explore the stress resistance mechanism to the digestive tract environment and the adhesive proteins of this strain, in this paper, we reported the complete genome sequence of KLDS 2.0603, which contains 19,469bp and encodes 1614 coding sequences(CDSs), 15 rRNA genes, 52 tRNA genes with 1678 open reading frames.
动物双歧杆菌乳亚种KLDS 2.0603（简称为KLDS 2.0603）是从一名成年人类粪便中分离出的益生菌菌株。先前的研究表明，KLDS 2.0603对模拟消化道条件具有高抗性，并且对肠道上皮细胞（Caco-2）具有高粘附能力。这两个特性是选择益生菌的基本要求。为了探索该菌株对消化道环境的抗逆机制及其粘附蛋白，在本文中，我们报道了KLDS 2.0603的完整基因组序列，其长度为19469bp，编码1614个编码序列（CDS）、15个rRNA基因、52个tRNA基因，共有1678个开放阅读框。
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