Clinica Medica I, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy.
Ann Rheum Dis. 2011 Nov;70(11):1937-43. doi: 10.1136/ard.2011.150508. Epub 2011 Aug 6.
Chondrocalcinosis is frequently associated with osteoarthritis. The role of osteoarthritis in the onset and progression of disability is well known. The impact of chondrocalcinosis on disability has never been investigated in epidemiological studies.
Progetto Veneto Anziani is a survey of 3099 older Italians, focusing on chronic diseases and disability. Assessment was by questionnaires, physical performance tests and clinical evaluations. Chondrocalcinosis was determined by x-ray readings of 1629 consecutive subjects. Knee and hip osteoarthritis severity was evaluated by summing the radiographic features score (RFS) assigned during x-ray reading.
with chondrocalcinosis were older and more frequently women (age-adjusted p<0.0001). The gender association disappeared following adjustment for osteoarthritis severity. However, at the knee, the prevalence of osteoarthritis was higher in chondrocalcinosis patients independently of age and sex (age-adjusted p<0.0001). No difference was found between chondrocalcinosis and controls in sociodemographic variables and comorbidity. Knee chondrocalcinosis was strongly associated with clinical features of knee osteoarthritis and with disability assessment parameters in the bivariate analysis. Most associations remained after adjusting for age. After further adjustment for RFS, a significant association remained for knee deformity and pain, the need for a cane, difficulty walking 500 m, using a toilet, shopping and repeatedly rising from a chair.
Pain and physical function are the outcome measures of choice for assessing disability in osteoarthritis patients. The presence of chondrocalcinosis contributes to both, independently of age and osteoarthritis severity, thus compromising the quality of life and worsening comorbidity.
软骨钙质沉着症常与骨关节炎相关。骨关节炎在残疾的发生和进展中的作用是众所周知的。软骨钙质沉着症对残疾的影响从未在流行病学研究中进行过调查。
Progetto Veneto Anziani 是一项对 3099 名意大利老年人的调查，重点关注慢性疾病和残疾。评估方法是通过问卷调查、身体机能测试和临床评估。软骨钙质沉着症通过对 1629 名连续受试者的 X 射线读数来确定。膝关节和髋关节骨关节炎严重程度通过在 X 射线阅读期间分配的放射特征评分（RFS）相加来评估。
患有软骨钙质沉着症的受试者年龄更大，且更常为女性（年龄调整后 p<0.0001）。在调整骨关节炎严重程度后，性别相关性消失。然而，在膝关节，无论年龄和性别如何，软骨钙质沉着症患者的骨关节炎患病率更高（年龄调整后 p<0.0001）。在社会人口统计学变量和合并症方面，软骨钙质沉着症与对照组之间没有差异。膝关节软骨钙质沉着症与膝关节骨关节炎的临床特征以及残疾评估参数在双变量分析中存在强烈相关性。在调整年龄后，大多数相关性仍然存在。在进一步调整 RFS 后，膝关节畸形和疼痛、需要使用手杖、行走 500 米困难、使用厕所、购物和反复从椅子上站起来等参数仍与软骨钙质沉着症相关。
疼痛和身体机能是评估骨关节炎患者残疾的首选结果指标。软骨钙质沉着症的存在与年龄和骨关节炎严重程度无关，会影响到疼痛和身体机能，从而降低生活质量并加重合并症。
