Petrusevska Marinkovic S, Kondova Topuzovska I, Milenkovic Z, Kondov G, Bosevska G, Anastasovska A
Infectious Diseases Clinic, Clinical Centre, Medical Faculty, Skopje, R. Macedonia.
Prilozi. 2011;32(1):101-11.
The aim of this study was to investigate the value and significance of interleukin-8 in differentiation of uncomplicated parapneumonic effusion (UCPPE) from complicated parapneumonic effusion (CPPE). Using an IMMULITE 1000 Analyzer, with chemiluminescent immunometric assay, levels of interleukin-8 (IL-8) were measured in the pleural fluid of patients with UCPPE (n=30), and CPPE (n=30), and three classical parameters (pH, glucose, and LDH) in these two groups. Receiver-operating curves were to assess the sensitivity and specifity of interleukin-8 for differentiating between the two patient groups. IL-8 levels were statistically higher in the CPPE group. A positive significant correlation, was found between levels of IL-8 and and lactate dehydrogenase (LDH) (r=0.68, p<0.05). There was also a positive significant correlation between IL-8 and protein level in pleural effusion (r=0.306, r<0.01). There was a significant negative correlation between levels of IL-8 and pH (r=-0.83, p<0.05), and of IL-8 and glucose in pleural fluid (r=-0.61, p<0.05). A cut-off value of 1805.81 pg/ml, differentiated CPPE from UPPE with a sensitivity of 100% and a specifity of 98%. IL-8 may be used as an alternative marker for the complication of parapneumonic effusion.
本研究旨在探讨白细胞介素-8在鉴别单纯性类肺炎性胸腔积液（UCPPE）与复杂性类肺炎性胸腔积液（CPPE）中的价值和意义。使用IMMULITE 1000分析仪，采用化学发光免疫分析法，测定了UCPPE患者（n = 30）和CPPE患者（n = 30）胸腔积液中的白细胞介素-8（IL-8）水平，以及这两组患者的三个经典参数（pH、葡萄糖和乳酸脱氢酶）。绘制受试者工作特征曲线以评估白细胞介素-8区分两组患者的敏感性和特异性。CPPE组的IL-8水平在统计学上更高。发现IL-8水平与乳酸脱氢酶（LDH）之间存在显著正相关（r = 0.68，p < 0.05）。IL-8与胸腔积液中的蛋白水平之间也存在显著正相关（r = 0.306，r < 0.01）。IL-8水平与pH之间存在显著负相关（r = -0.83，p < 0.05），与胸腔积液中的葡萄糖之间也存在显著负相关（r = -0.61，p < 0.05）。以1805.81 pg/ml为临界值，区分CPPE与UPPE的敏感性为100%，特异性为98%。IL-8可作为类肺炎性胸腔积液并发症的替代标志物。
