Department of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Nano Lett. 2011 Sep 14;11(9):3744-50. doi: 10.1021/nl201782m. Epub 2011 Aug 10.
Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to render water solubility, biocompatibility, and low cellular toxicity. Optical imaging of integrin α(v)β(3) on U87MG human glioblastoma cells was achieved with RGD peptide-conjugated green fluorescent ZnO NWs, which opened up new avenues of research for investigating ZnO NW-based agents in tumor vasculature-targeted molecular imaging and drug delivery.
在这里,我们证明了经过功能化处理以提高水溶性、生物相容性和低细胞毒性后,本征发荧光的氧化锌(ZnO)纳米线(NWs)可用于癌细胞的分子靶向成像。用 RGD 肽偶联的绿色荧光 ZnO NWs 实现了 U87MG 人神经胶质瘤细胞整联蛋白 α(v)β(3)的光学成像,这为研究基于 ZnO NW 的制剂在肿瘤血管靶向分子成像和药物输送中的应用开辟了新的途径。