Rocha Cátia Vieira, Gonçalves Victor, da Silva Milene Costa, Bañobre-López Manuel, Gallo Juan
Advanced (Magnetic) Theranostic Nanostructures Lab, Health Cluster, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal.
Int J Mol Sci. 2022 Feb 12;23(4):2034. doi: 10.3390/ijms23042034.
Polymeric materials have been extensively explored in the field of nanomedicine; within them, poly lactic-co-glycolic acid (PLGA) holds a prominent position in micro- and nanotechnology due to its biocompatibility and controllable biodegradability. In this review we focus on the combination of PLGA with different inorganic nanomaterials in the form of nanocomposites to overcome the polymer's limitations and extend its field of applications. We discuss their physicochemical properties and a variety of well-established synthesis methods for the preparation of different PLGA-based materials. Recent progress in the design and biomedical applications of PLGA-based materials are thoroughly discussed to provide a framework for future research.
高分子材料在纳米医学领域已得到广泛探索；其中，聚乳酸-羟基乙酸共聚物（PLGA）因其生物相容性和可控的生物降解性，在微纳技术领域占据突出地位。在本综述中，我们重点关注PLGA与不同无机纳米材料以纳米复合材料的形式相结合，以克服聚合物的局限性并扩展其应用领域。我们讨论了它们的物理化学性质以及用于制备不同PLGA基材料的各种成熟合成方法。全面讨论了基于PLGA材料在设计和生物医学应用方面的最新进展，以为未来研究提供一个框架。
