Centre Cardiologique du Nord, Saint-Denis, Paris, France.
Clin Nucl Med. 2011 Sep;36(9):776-80. doi: 10.1097/RLU.0b013e31821a294e.
Cadmium zinc telluride (CZT) solid-state detectors have been recently introduced in myocardial perfusion imaging. However, they had not been yet validated with thallium-201. This study compares the clinical performances of the CZT ultrafast camera GE DNM 530c with a conventional SPECT camera (CC) using thallium-201.
We prospectively studied with thallium-201 a total of 153 consecutive patients referred for myocardial perfusion imaging at exercise (3-4 mCi) then redistribution (with 1 mCi reinjection). Sequential acquisitions were performed first with a conventional dual-head tomographic Anger camera (CC) in 10 to 15 minutes and then with a CZT camera (CZT) in 5 minutes, in prone position.
In all, 9 patients were excluded: 1 for mispositioning, 3 for camera failure, 3 for delayed acquisition after exercise, 1 for nonacceptance of redistribution, 1 for motion. Acquisition was more comfortable with CZT for all patients. Global counts rate was higher with CZT than with CC (3.6±0.57 KCts/s vs. 1.14±0.16). CZT has a 5-fold increased myocardial counts rate compared with CC (448±69 Kcts in 5 minutes vs. 209±40 Kcts in 12.5±1.8 minutes). Quality of CZT images was considered as better in 40%, equal in 56%, and worse in 4% of cases; we found less artifacts with CZT; diagnostic conclusions were the same in 140 of 144 cases (97%); discordances were 2 artifacts with CC and 2 small ischemia (less than 2 segments) missed by CZT.
This new dedicated cardiac CZT camera allows with thallium-201 five minutes acquisitions with an increased image quality and a reliable diagnosis quality.
碲锌镉（CZT）固体探测器最近已被引入心肌灌注成像。然而，它们尚未与铊-201 进行验证。本研究比较了 CZT 超快速相机 GE DNM 530c 与传统单光子发射计算机断层扫描（SPECT）相机（CC）使用铊-201 的临床性能。
我们前瞻性地研究了 153 例连续患者，他们在运动（3-4mCi）后进行铊-201 心肌灌注成像，然后进行再分布（用 1mCi 再注射）。首先在 10 到 15 分钟内使用传统的双探头断层扫描型 Anger 相机（CC）进行连续采集，然后在 5 分钟内以俯卧位使用 CZT 相机（CZT）进行采集。
共有 9 例患者被排除：1 例因定位错误，3 例因相机故障，3 例因运动后采集延迟，1 例因不接受再分布，1 例因运动。所有患者均表示 CZT 采集更舒适。与 CC 相比，CZT 的全局计数率更高（3.6±0.57KCts/s 比 1.14±0.16）。与 CC 相比，CZT 的心肌计数率增加了 5 倍（5 分钟内 448±69 Kcts 比 12.5±1.8 分钟内 209±40 Kcts）。CZT 图像质量被认为在 40%的病例中更好，在 56%的病例中相等，在 4%的病例中更差；我们发现 CZT 图像的伪影更少；144 例中有 140 例（97%）的诊断结论相同；有 2 例 CC 出现的伪影和 2 例 CZT 漏诊的小范围缺血（小于 2 个节段）。
这种新型专用心脏 CZT 相机允许使用铊-201 进行 5 分钟采集，具有更高的图像质量和可靠的诊断质量。
