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血清反应阳性成人中减毒活甲型H1N1和H3N2流感病毒疫苗的使用。

Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults.

作者信息

Treanor J J, Roth F K, Betts R F

机构信息

Department of Medicine, University of Rochester School of Medicine, New York 14642.

出版信息

J Clin Microbiol. 1990 Mar;28(3):596-9. doi: 10.1128/jcm.28.3.596-599.1990.

DOI:10.1128/jcm.28.3.596-599.1990
PMID:2182673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC269668/
Abstract

To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-adapted vaccines were immunogenic in seropositive adults. In addition, individuals receiving cold-adapted vaccines had lower rates of virus shedding and illness following challenge with wild-type influenza virus than did unvaccinated seropositive volunteers.

摘要

为了研究冷适应流感疫苗对甲型流感病毒具有基础免疫力个体的免疫原性和保护效力，我们对疫苗接种前血清血凝抑制抗体滴度为1:16或更高的成年人接种了冷适应H1N1和H3N2疫苗，并在1个月后用同源野生型甲型流感病毒对他们进行攻击。两种冷适应疫苗在血清阳性成年人中均具有免疫原性。此外，与未接种疫苗的血清阳性志愿者相比，接种冷适应疫苗的个体在受到野生型流感病毒攻击后病毒脱落率和发病率更低。

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本文引用的文献

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Cold-adapted recombinant influenza A virus vaccines in seronegative young children.血清阴性幼儿中的冷适应重组甲型流感病毒疫苗
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Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine.血清阴性和血清阳性成年志愿者对冷适应减毒活重组甲型流感病毒疫苗的反应。
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Use of influenza A virus vaccines in seronegative children: live cold-adapted versus inactivated whole virus.甲型流感病毒疫苗在血清阴性儿童中的应用：冷适应活疫苗与全病毒灭活疫苗的比较。
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