Wright P F, Okabe N, McKee K T, Maassab H F, Karzon D T
J Infect Dis. 1982 Jul;146(1):71-9. doi: 10.1093/infdis/146.1.71.
Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In addition, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.
在范德比尔特儿童医院（田纳西州纳什维尔），对21名血清学阴性的幼儿评估了两种经鼻内接种的减毒活流感病毒疫苗。这些疫苗是冷适应主毒株甲型流感/安阿伯/6/60病毒的衍生物，含有两种当代毒株之一甲型流感/香港/123/77（H1N1）或甲型流感/阿拉斯加/6/77（H3N2）病毒的血凝素和神经氨酸酶。两种疫苗毒株均在血清学阴性的幼儿中复制，且无基因不稳定的迹象。此外，两种疫苗毒株均未引起可识别的临床反应，未传播给其他血清学阴性儿童，并提供了持久的免疫力。在随后发生的甲型流感/曼谷（H3N2）病毒自然流行中，根据再次感染的血清学证据判断，先前接种过相关毒株甲型流感/阿拉斯加（H3N2）病毒的儿童受到了显著保护。
