血清阴性和血清阳性成年志愿者对冷适应减毒活重组甲型流感病毒疫苗的反应。
Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine.
作者信息
Clements M L, Tierney E L, Murphy B R
出版信息
J Clin Microbiol. 1985 Jun;21(6):997-9. doi: 10.1128/jcm.21.6.997-999.1985.
Abstract
The infectivity and immunogenicity of live attenuated A/Washington/897/80 cold-adapted reassortant virus vaccine was evaluated in seronegative (hemagglutination inhibition titer, less than or equal to 1:4) and seropositive (hemagglutination inhibition titer, greater than 1:4) adult volunteers. The vaccine was efficient in infecting seronegative volunteers (94%). Moreover, 51% of seropositive vaccinees were infected by the virus. After live virus vaccination, greater than 83% of both seronegative and seropositive vaccinees achieved a level of nasal wash antibody previously associated with resistance to infection with influenza A virus. These findings indicate that both seronegative and seropositive vaccinees can benefit from live virus vaccination.
摘要
在血清阴性（血凝抑制效价小于或等于1:4）和血清阳性（血凝抑制效价大于1:4）的成年志愿者中评估了减毒活A/华盛顿/897/80冷适应重配病毒疫苗的感染性和免疫原性。该疫苗能有效感染血清阴性志愿者（94%）。此外，51%的血清阳性接种者被该病毒感染。接种活病毒疫苗后，血清阴性和血清阳性接种者中均有超过83%的人达到了先前与甲型流感病毒感染抗性相关的鼻腔冲洗抗体水平。这些发现表明，血清阴性和血清阳性接种者均可从活病毒疫苗接种中获益。
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