Landin K, Tengborn L, Smith U
Department of Medicine II, Gothenburg University, Sahlgren's Hospital, Sweden.
J Intern Med. 1990 Apr;227(4):273-8. doi: 10.1111/j.1365-2796.1990.tb00157.x.
The relationship between hypertension, glucose metabolism, fibrinogen and plasminogen activator inhibitor of endothelial cell type (PAI-1) was studied under conditions in which the influence of obesity and adipose tissue distribution (waist/hip ratio) were controlled. Twenty-two non-obese, middle-aged men with normal blood pressure (n = 11) and untreated mild hypertension (n = 11), respectively, participated in the study. Cholesterol, triglyceride and insulin levels were higher in hypertensive men than in the control group. Glucose disposal was studied as an indicator of insulin sensitivity using the euglycaemic clamp technique. The insulin effect tended to be less marked in men with hypertension. PAI-1 was higher in hypertensive men compared to the controls. A strong positive correlation was observed between PAI-1 and insulin levels as well as blood pressure. PAI-1 and fibrinogen levels correlated negatively with the rate of glucose disposal. Thus, even in these non-obese and mildly hypertensive individuals, an enhanced metabolic risk factor profile for cardiovascular disease was found. The metabolic aberrations were related to elevated fibrinogen and PAI-1 levels which, in turn, increase the risk of thrombus formation.
在控制肥胖及脂肪组织分布（腰臀比）影响的条件下，研究了高血压、糖代谢、纤维蛋白原与内皮细胞型纤溶酶原激活物抑制剂（PAI-1）之间的关系。22名非肥胖中年男性参与了该研究，其中11名血压正常，11名患有未经治疗的轻度高血压。高血压男性的胆固醇、甘油三酯和胰岛素水平高于对照组。使用正常血糖钳夹技术研究葡萄糖处置情况作为胰岛素敏感性指标。高血压男性的胰岛素作用往往不太明显。与对照组相比，高血压男性的PAI-1水平更高。观察到PAI-1与胰岛素水平以及血压之间存在强正相关。PAI-1和纤维蛋白原水平与葡萄糖处置率呈负相关。因此，即使在这些非肥胖和轻度高血压个体中，也发现心血管疾病的代谢危险因素谱有所增强。代谢异常与纤维蛋白原和PAI-1水平升高有关，进而增加血栓形成风险。
