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代谢综合征：马的疾病与人的疾病有可比性吗？

Metabolic syndrome: is equine disease comparable to what we know in humans?

机构信息

Equine ClinicFree University of Berlin, Berlin, Germany

Equine ClinicFree University of Berlin, Berlin, Germany.

出版信息

Endocr Connect. 2014 Sep;3(3):R81-93. doi: 10.1530/EC-14-0038. Epub 2014 Jun 3.

DOI:10.1530/EC-14-0038
PMID:24894908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4068110/
Abstract

This review summarizes similarities and differences between the metabolic syndromes in humans and equines, concerning the anatomy, symptoms, and pathophysiological mechanisms. In particular, it discusses the structure and distribution of adipose tissue and its specific metabolic pathways. Furthermore, this article provides insights and focuses on issues concerning laminitis in horses and cardiovascular diseases in humans, as well as their overlap.

摘要

这篇综述总结了人类和马的代谢综合征在解剖学、症状和病理生理学机制方面的异同。特别是，它讨论了脂肪组织的结构和分布及其特定的代谢途径。此外，本文还探讨了马的蹄叶炎和人类的心血管疾病的相关问题及其重叠之处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/1c610672ddf5/ec-03-R81-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/d1573431a93a/ec-03-R81-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/a2ad89ed0d65/ec-03-R81-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/1c610672ddf5/ec-03-R81-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/d1573431a93a/ec-03-R81-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/a2ad89ed0d65/ec-03-R81-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a62b/4068110/1c610672ddf5/ec-03-R81-g003.jpg

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本文引用的文献

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Cholesterol control according to the presence of metabolic syndrome in coronary and diabetic patients. Relationship with non-alcoholic fatty liver disease.根据冠心病和糖尿病患者代谢综合征的存在情况进行胆固醇控制。与非酒精性脂肪性肝病的关系。
Eur J Intern Med. 2014 Jun;25(5):438-43. doi: 10.1016/j.ejim.2014.03.014. Epub 2014 Apr 5.
2
Effect of short-term hyperinsulinemia on the localization and expression of endothelin receptors A and B in lamellar tissue of the forelimbs of horses.短期高胰岛素血症对马前肢板层组织中内皮素A和B受体定位及表达的影响。
Am J Vet Res. 2014 Apr;75(4):367-74. doi: 10.2460/ajvr.75.4.367.
3
性激素结合球蛋白可改善脂质代谢并减轻患代谢综合征马匹皮下脂肪组织的炎症。
Front Mol Biosci. 2023 Dec 11;10:1214961. doi: 10.3389/fmolb.2023.1214961. eCollection 2023.
4
Effects of corn supplementation on serum and muscle microRNA profiles in horses.玉米补充剂对马血清和肌肉微小RNA谱的影响。
Food Sci Nutr. 2023 Feb 14;11(6):2811-2822. doi: 10.1002/fsn3.3259. eCollection 2023 Jun.
5
Thromboelastography in obese horses with insulin dysregulation compared to healthy controls.肥胖且存在胰岛素紊乱的马与健康对照马的血栓弹力描记术比较。
J Vet Intern Med. 2022 May;36(3):1131-1138. doi: 10.1111/jvim.16421. Epub 2022 Apr 16.
6
Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders.患有代谢和炎症性疾病马匹血浆抵抗素浓度的测定。
Animals (Basel). 2021 Dec 30;12(1):77. doi: 10.3390/ani12010077.
7
Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes In Vitro and Ex Vivo.性激素结合球蛋白 (SHBG) 减轻了肝细胞体外和体内的内质网应激。
Cells. 2021 Mar 30;10(4):755. doi: 10.3390/cells10040755.
8
MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress.MSI-1436 通过调节内质网应激、细胞凋亡和氧化应激，改善了 EMS 脂肪来源祖细胞在成脂分化过程中的状态。
Stem Cell Res Ther. 2021 Feb 3;12(1):97. doi: 10.1186/s13287-020-02102-x.
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Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.解偶联蛋白（UCP）基因多态性与心脏代谢疾病的关系。
Mol Med. 2020 May 25;26(1):51. doi: 10.1186/s10020-020-00180-4.
10
Expression of immune regulatory genes correlate with the abundance of specific Clostridiales and Verrucomicrobia species in the equine ileum and cecum.免疫调节基因的表达与马回肠和盲肠中特定梭菌属和疣微菌属物种的丰度相关。
Sci Rep. 2019 Sep 3;9(1):12674. doi: 10.1038/s41598-019-49081-5.
Nonalcoholic fatty liver disease: for better or worse, blame the gut microbiota?
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JPEN J Parenter Enteral Nutr. 2013 Nov;37(6):787-93. doi: 10.1177/0148607113481623. Epub 2013 Mar 28.
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Significance of the presence of metabolic syndrome in patients with asymptomatic arteriosclerosis affecting the aorta and the cerebral, extra-cranial carotid and coronary arteries.代谢综合征在影响主动脉、脑、颅外颈动脉和冠状动脉的无症状动脉硬化患者中的意义。
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Curr Nutr Rep. 2013 Mar;2(1):1-9. doi: 10.1007/s13668-012-0036-9. Epub 2012 Dec 16.
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A potential role for lamellar insulin-like growth factor-1 receptor in the pathogenesis of hyperinsulinaemic laminitis.层粘连蛋白胰岛素样生长因子-1 受体在高胰岛素血症性蹄叶炎发病机制中的潜在作用。
Vet J. 2013 Aug;197(2):302-6. doi: 10.1016/j.tvjl.2012.12.026. Epub 2013 Feb 8.
10
Impaired coronary flow reserve evaluated by echocardiography is associated with increased aortic stiffness in patients with metabolic syndrome: an observational study.
Anadolu Kardiyol Derg. 2013 May;13(3):227-34. doi: 10.5152/akd.2013.068. Epub 2013 Jan 30.