Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Japan.
Adv Drug Deliv Rev. 2012 May 1;64(6):523-30. doi: 10.1016/j.addr.2011.07.003. Epub 2011 Jul 30.
Oral vaccine has been considered to be a prospective vaccine against many pathogens especially invading across gastrointestinal tracts. One key element of oral vaccine is targeting efficient delivery of antigen to gut-associated lymphoid tissue (GALT), the inductive site in the intestine where antigen-specific immune responses are initiated. Various chemical and biological antigen delivery systems have been developed and some are in clinical trials. In this review, we describe the immunological features of GALT and the current status of antigen delivery system candidates for successful oral vaccine.
口服疫苗被认为是针对许多病原体的有前途的疫苗，特别是针对通过胃肠道入侵的病原体。口服疫苗的一个关键要素是将抗原靶向递送到肠相关淋巴组织（GALT），GALT 是肠道中启动抗原特异性免疫应答的诱导部位。已经开发了各种化学和生物抗原递送系统，其中一些正在临床试验中。在这篇综述中，我们描述了 GALT 的免疫学特征和成功的口服疫苗的抗原递送系统候选物的现状。
