Infectious Diseases Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Infect Control Hosp Epidemiol. 2011 Sep;32(9):831-6. doi: 10.1086/661104.
New technologies have emerged in recent years for the disinfection of hospital rooms and equipment that may not be disinfected adequately using conventional methods. There are several hydrogen peroxide-based area decontamination technologies on the market, but no head-to-head studies have been performed.
We conducted a head-to-head in vitro comparison of a hydrogen peroxide vapor (HPV) system (Bioquell) and an aerosolized hydrogen peroxide (aHP) system (Sterinis).
The tests were conducted in a purpose-built 136-m(3) test room.
One HPV generator and 2 aHP machines were used, following recommendations of the manufacturers. Three repeated tests were performed for each system. The microbiological efficacy of the 2 systems was tested using 6-log Tyvek-pouched Geobacillus stearothermophilus biological indicators (BIs). The indicators were placed at 20 locations in the first test and 14 locations in the subsequent 2 tests for each system.
All BIs were inactivated for the 3 HPV tests, compared with only 10% in the first aHP test and 79% in the other 2 aHP tests. The peak hydrogen peroxide concentration was 338 ppm for HPV and 160 ppm for aHP. The total cycle time (including aeration) was 3 and 3.5 hours for the 3 HPV tests and the 3 aHP tests, respectively. Monitoring around the perimeter of the enclosure with a handheld sensor during tests of both systems did not identify leakage.
One HPV generator was more effective than 2 aHP machines for the inactivation of G. stearothermophilus BIs, and cycle times were faster for the HPV system.
近年来出现了一些新技术，可用于对医院房间和设备进行消毒，而常规方法可能无法充分消毒这些房间和设备。市场上有几种基于过氧化氢的区域去污技术，但尚未进行过直接比较的研究。
我们在一个专门建造的 136 立方米测试室中，对一种过氧化氢蒸气（HPV）系统（Bioquell）和一种雾化过氧化氢（aHP）系统（Sterinis）进行了直接比较的体外测试。
根据制造商的建议，使用了一个 HPV 发生器和 2 个 aHP 机器。每个系统进行了 3 次重复测试。使用 6 对数 Tyvek 包裹的嗜热脂肪芽孢杆菌生物指示剂（BI）测试了这 2 个系统的微生物效能。第一次测试中，将 BI 放在 20 个位置，随后 2 次测试中，每个系统放置在 14 个位置。
HPV 的 3 次测试中所有 BI 都被灭活，而 aHP 的第一次测试中只有 10%被灭活，随后 2 次测试中只有 79%被灭活。HPV 的过氧化氢峰值浓度为 338ppm，aHP 的为 160ppm。HPV 的 3 次测试和 aHP 的 3 次测试的总循环时间（包括通风）分别为 3 小时和 3.5 小时。在测试这两个系统时，用手持式传感器在外壳周围进行监测，未发现泄漏。
与 2 个 aHP 机器相比，1 个 HPV 发生器更有效地使嗜热脂肪芽孢杆菌 BI 失活，HPV 系统的循环时间更快。
