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生物战剂

Biological warfare agents.

作者信息

Thavaselvam Duraipandian, Vijayaraghavan Rajagopalan

机构信息

Defence Research and Development Establishment, Jhansi Road, Gwalior - 474 002, India.

出版信息

J Pharm Bioallied Sci. 2010 Jul;2(3):179-88. doi: 10.4103/0975-7406.68499.

Abstract

The recent bioterrorist attacks using anthrax spores have emphasized the need to detect and decontaminate critical facilities in the shortest possible time. There has been a remarkable progress in the detection, protection and decontamination of biological warfare agents as many instrumentation platforms and detection methodologies are developed and commissioned. Even then the threat of biological warfare agents and their use in bioterrorist attacks still remain a leading cause of global concern. Furthermore in the past decade there have been threats due to the emerging new diseases and also the re-emergence of old diseases and development of antimicrobial resistance and spread to new geographical regions. The preparedness against these agents need complete knowledge about the disease, better research and training facilities, diagnostic facilities and improved public health system. This review on the biological warfare agents will provide information on the biological warfare agents, their mode of transmission and spread and also the detection systems available to detect them. In addition the current information on the availability of commercially available and developing technologies against biological warfare agents has also been discussed. The risk that arise due to the use of these agents in warfare or bioterrorism related scenario can be mitigated with the availability of improved detection technologies.

摘要

近期利用炭疽芽孢进行的生物恐怖袭击凸显了在尽可能短的时间内检测并清除关键设施内生物制剂的必要性。随着众多仪器平台和检测方法的研发与投入使用,在生物战剂的检测、防护和清除方面已取得显著进展。即便如此,生物战剂的威胁及其在生物恐怖袭击中的使用仍然是全球关注的主要原因。此外,在过去十年中,由于新出现的疾病、旧疾病的再度出现、抗微生物药物耐药性的发展以及向新地理区域的传播,一直存在着威胁。针对这些制剂的防范需要全面了解疾病、更好的研究和培训设施、诊断设施以及完善的公共卫生系统。这篇关于生物战剂的综述将提供有关生物战剂、其传播方式以及用于检测它们的现有检测系统的信息。此外,还讨论了目前有关针对生物战剂的商用和正在研发的技术的信息。通过改进检测技术,可以降低在战争或与生物恐怖主义相关的场景中使用这些制剂所产生的风险。

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