Department of Obstetrics and Gynecology Clinic III, Izmir Ataturk Training and Research Hospital, Izmir, Turkey.
Arch Gynecol Obstet. 2012 Mar;285(3):805-10. doi: 10.1007/s00404-011-2034-3. Epub 2011 Aug 10.
This study aimed to identify the effect of various risk factors as the promoters of HPV infection, and to identify which HPV-positive women may have an increased risk of developing cervical cancer.
Smear preparations were examined and classified according to the Bethesda system. HPV-DNA detection and genotyping was carried out using polymerase chain reaction combined with reverse hybridization line-probe assays. Age, smoking habit, age at first sexual intercourse, number of sexual partners, number of term births, contraceptive method, progesterone therapy, history of sexually transmitted diseases, history or existence of warts and existence of cervical infection were recorded.
642 women (96 women with abnormal cervical cytology and 546 women with normal cytology) provided cervical samples. Smoking habit, number of sexual partners, number of term births, history of sexually transmitted diseases, history or existence of warts and existence of cervical infection were identified as the promoters of HPV infection. History of sexually transmitted diseases, history or existence of warts and existence of cervical infection were identified as cofactors affecting progression from HPV infection to cervical cancer. Neither of contraceptive methods studied was related to HPV infection or coexistence with malign transformation to cervical cancer.
Information gathered from this study could be used to prioritize limited screening and treatment services to woman who have specific characteristics that may put them at an increased risk of HPV infection. Additionally, by identifying which women have a higher risk of cervical cancer; it may be possible to reduce the number of unnecessary colposcopies.
本研究旨在确定各种危险因素作为 HPV 感染促进因素的作用，并确定哪些 HPV 阳性妇女可能有更高的宫颈癌发病风险。
采用巴氏系统对涂片进行检查和分类。采用聚合酶链反应结合反向杂交线探针分析进行 HPV-DNA 检测和基因分型。记录年龄、吸烟习惯、初次性行为年龄、性伴侣数量、足月产次数、避孕方法、孕激素治疗、性传播疾病史、疣病史或存在、宫颈感染史。
642 名妇女（96 名宫颈细胞学异常妇女和 546 名细胞学正常妇女）提供了宫颈样本。吸烟习惯、性伴侣数量、足月产次数、性传播疾病史、疣病史或存在、宫颈感染被确定为 HPV 感染的促进因素。性传播疾病史、疣病史或存在、宫颈感染被确定为影响 HPV 感染向宫颈癌进展的协同因素。研究中没有一种避孕方法与 HPV 感染或与宫颈癌恶变共存有关。
从本研究中收集的信息可用于优先考虑对具有特定特征的妇女进行有限的筛查和治疗服务，这些特征可能使她们面临更高的 HPV 感染风险。此外，通过确定哪些妇女有更高的宫颈癌发病风险，可能减少不必要的阴道镜检查数量。
