Department of Oral Pathology, Faculty of Dentistry, College of Medicine, University of Ibadan, Nigeria.
J Natl Med Assoc. 2011 Jun;103(6):498-502. doi: 10.1016/s0027-9684(15)30364-3.
Oral squamous cell carcinoma, traditionally a disease of elderly men with a history of chronic exposure to the carcinogenic effects of tobacco and alcohol, is presently being more frequently diagnosed both in a younger patient population and in those not exposed to these carcinogenic substances. At our center, most patients with oral squamous cell carcinoma are not involved in the use of tobacco or alcoholic beverages and are mainly of a low socioeconomic class. This hospital-based case-control study was designed to assess if the risk of developing intraoral squamous cell carcinoma in Ibadan, Nigeria, was associated with the use of tobacco, alcohol, or socioeconomic status. Medical records of patients with histological diagnosis of squamous cell carcinoma of the oral cavity at the University College Hospital, Ibadan, between January 1990 and December 2008 were analyzed. Only 26% of patients gave a positive history of exposure to tobacco, alcohol, or both; of this number, 20.3% used tobacco, while 18.8% consumed alcohol and 13% used both. Although 24.6% of the cases were of high socioeconomic class, there was no significant difference in the distribution of oral cancer patients in the 2 socioeconomic classes. This study revealed an important deviation from expected amongst the oral squamous cell carcinoma patients diagnosed at Ibadan, thus raising the possibility of a different etiology for oral cancer in our population and the need for research focused on identifying possible risk factors.
口腔鳞状细胞癌，传统上是一种发生于老年男性的疾病，他们有长期接触烟草和酒精致癌作用的病史，目前在年轻患者人群和未接触这些致癌物质的人群中更为频繁地被诊断出来。在我们中心，大多数口腔鳞状细胞癌患者不使用烟草或酒精饮料，主要来自社会经济地位较低的人群。本项以医院为基础的病例对照研究旨在评估在尼日利亚伊巴丹，发生口腔内鳞状细胞癌的风险是否与使用烟草、酒精或社会经济地位有关。分析了 1990 年 1 月至 2008 年 12 月期间在伊巴丹大学教学医院被诊断为口腔鳞状细胞癌的患者的医疗记录。只有 26%的患者有明确的接触烟草、酒精或两者的病史；在这一数字中，20.3%的患者使用烟草，18.8%的患者饮酒，13%的患者同时使用烟草和酒精。尽管 24.6%的病例来自社会经济地位较高的人群，但在这两个社会经济阶层中，口腔癌患者的分布没有显著差异。这项研究揭示了在伊巴丹诊断出的口腔鳞状细胞癌患者中存在一个重要的偏离预期的情况，因此，我们人群中口腔癌可能存在不同的病因，需要集中研究以确定可能的风险因素。
