She Yangyang, Nong Xiaolin, Zhang Min, Wang Menglin
Department of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.
Department of Prosthodontics, College and Hospital of Stomatology, Peking University, Beijing, China.
PLoS One. 2017 Oct 24;12(10):e0186860. doi: 10.1371/journal.pone.0186860. eCollection 2017.
The evidence for association between Epstein-Barr virus (EBV) infection and risk of oral squamous cell carcinoma (OSCC) is inconsistent in the literature. Therefore, this meta-analysis was conducted to clarify this association.
A literature search was conducted in electronic databases for English- and Chinese-language publications until March 31, 2017 to include eligible case-control studies. The pooled odds ratio (OR) and 95% confidence interval (95% CI) were estimated to determine the association between EBV infection and OSCC risk using a fixed- or random-effects model based on heterogeneity. Publication bias was assessed using funnel plot analysis.
A total of 13 case-control studies with 686 OSCC patients and 433 controls were included based on predetermined inclusion and exclusion criteria. The pooled OR with 95% CI between EBV infection and OSCC risk was 5.03 (1.80-14.01) with significant heterogeneity observed (I2 = 87%). The subgroup analysis indicates that the year of publication, study location, economic level, sample size, tissue type, detection method and marker, control type, and language might explain potential sources of heterogeneity. Publication bias was not observed, and sensitivity analysis showed stable results.
The results of the current meta-analysis suggest that EBV infection is statistically associated with increased risk of OSCC. However, additional high-quality studies with larger sample sizes are needed to further confirm the relationship between EBV and OSCC.
文献中关于爱泼斯坦-巴尔病毒（EBV）感染与口腔鳞状细胞癌（OSCC）风险之间关联的证据并不一致。因此，进行了这项荟萃分析以阐明这种关联。
在电子数据库中检索截至2017年3月31日的英文和中文出版物，以纳入符合条件的病例对照研究。根据异质性采用固定效应或随机效应模型估计合并比值比（OR）和95%置信区间（95%CI），以确定EBV感染与OSCC风险之间的关联。使用漏斗图分析评估发表偏倚。
根据预先确定的纳入和排除标准，共纳入13项病例对照研究，其中有686例OSCC患者和433例对照。EBV感染与OSCC风险之间的合并OR（95%CI）为5.03（1.80 - 14.01），观察到显著的异质性（I² = 87%）。亚组分析表明，发表年份、研究地点、经济水平、样本量、组织类型、检测方法和标志物、对照类型以及语言可能解释异质性的潜在来源。未观察到发表偏倚，敏感性分析显示结果稳定。
当前荟萃分析的结果表明，EBV感染在统计学上与OSCC风险增加相关。然而，需要更多高质量、大样本量的研究来进一步证实EBV与OSCC之间的关系。
