人血浆中黄芩素代谢产物的鉴定。

Identification of the metabolites of baicalein in human plasma.

作者信息

Guo Xiao-Yu, Yang Lin, Chen Ying, Wang Qi-Fang, Sun Qi-Shi, Che Yi-Xin, Che Qing-Ming

机构信息

Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

出版信息

J Asian Nat Prod Res. 2011 Sep;13(9):861-8. doi: 10.1080/10286020.2011.599321.

DOI:10.1080/10286020.2011.599321

PMID:21830892

Abstract

The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.

摘要

服用黄芩苷（黄芩中的主要生物活性黄酮之一）后，对人血浆中黄芩苷的代谢产物进行了研究。通过高效液相色谱-二极管阵列检测器（DAD）和液相色谱-串联质谱（LC-MS/MS）方法检测并鉴定了5种代谢产物（M1-M5）以及母体药物黄芩苷（P）。其中，7-甲氧基黄芩苷6-O-葡萄糖醛酸苷（M5）是一种新的代谢产物。基于这些结果，推断了黄芩苷在人体内的代谢途径。