Wang Meng-Hua, Li Lin-Zhen, Sun Jian-Bo, Wu Fei-Hua, Liang Jing-Yu
a Department of Natural Medicinal Chemistry , China Pharmaceutical University , 639 Longmian Avenue, Nanjing 211198 , P.R. China.
Nat Prod Res. 2014;28(20):1772-6. doi: 10.1080/14786419.2014.931391. Epub 2014 Jul 4.
A new flavone glycoside, wogonin 7-O-β-D-ethylglucuronide (1), together with a new natural flavone glycoside baicalein 7-O-β-D-ethylglucuronide (2) and four known analogues, wogonoside (3), wogonin (4), oroxylin A 7-O-β-D-methylglucuronide (5) and oroxylin A (6), was isolated from the roots of Scutellaria baicalensis Georgi. The structure elucidation of the new compound was primarily based on HR-ESI-MS, 1D and 2D NMR analyses. Compounds 1 and 3 inhibited FeSO4-Cys-induced liver homogenate lipid peroxidation with IC50 at 18.2 μM and 24.9 μM, respectively, and exhibited strong cytoprotective effects against H2O2-induced oxidative damage in human umbilical vein endothelial cells at low concentrations of 10.0 μM and 3.0 μM.
从黄芩（Scutellaria baicalensis Georgi）根中分离出一种新的黄酮苷，汉黄芩素7 - O - β - D - 乙基葡萄糖醛酸苷（1），以及一种新的天然黄酮苷黄芩苷元7 - O - β - D - 乙基葡萄糖醛酸苷（2）和四种已知类似物，黄芩苷（3）、汉黄芩素（4）、木犀草素7 - O - β - D - 甲基葡萄糖醛酸苷（5）和木犀草素（6）。新化合物的结构解析主要基于高分辨电喷雾电离质谱（HR - ESI - MS）、一维和二维核磁共振分析。化合物1和3抑制硫酸亚铁 - 半胱氨酸诱导的肝匀浆脂质过氧化，其半数抑制浓度（IC50）分别为18.2 μM和24.9 μM，并且在10.0 μM和3.0 μM的低浓度下，对过氧化氢诱导的人脐静脉内皮细胞氧化损伤表现出强大的细胞保护作用。
