Iyer Abishek, Kauter Kathleen, Brown Lindsay
School of Biomedical Sciences, The University of Queensland, St Lucia, Australia.
Endocr Metab Immune Disord Drug Targets. 2011 Sep 1;11(3):182-8. doi: 10.2174/187153011796429808.
Metabolic syndrome as a clustering of risk factors for diabetes and cardiovascular disease affects both men and women, but with important gender differences. Animal models have been used to understand disease progression and define therapeutic options, but most pre-clinical research on metabolic syndrome is undertaken in males. This opinion piece discusses the differences in male and female physiology that may influence both the development and the responses to pharmacological interventions of metabolic disorders, especially obesity. An appreciation of gender differences should improve the design and usefulness of biomedical experimental research to allow the development of relevant gender-based treatment options for chronic diseases including obesity, metabolic and cardiovascular diseases.
代谢综合征作为糖尿病和心血管疾病危险因素的聚集，对男性和女性均有影响，但存在重要的性别差异。动物模型已被用于了解疾病进展并确定治疗方案，但大多数关于代谢综合征的临床前研究是在雄性动物中进行的。这篇观点文章讨论了男性和女性生理上的差异，这些差异可能会影响代谢紊乱尤其是肥胖症的发生发展以及对药物干预的反应。认识到性别差异应能改善生物医学实验研究的设计和效用，从而开发出针对包括肥胖症、代谢性疾病和心血管疾病在内的慢性疾病的相关性别特异性治疗方案。
