Leermakers Elisabeth T M, Felix Janine F, Jaddoe Vincent W V, Raat Hein, Franco Oscar H, Kiefte-de Jong Jessica C
Generation R Study Group, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, University Medical Center Rotterdam, room Na 2909, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Int J Behav Nutr Phys Act. 2015 Sep 17;12:114. doi: 10.1186/s12966-015-0278-1.
Consumption of sugar-containing beverages (SCBs) in adults has been associated with an increased risk of metabolic syndrome. Although the effect of SCB on body weight in children is well established, little is known about the cardiometabolic effects in young children. We studied the associations of SCB intake at the age of 1 year with cardiometabolic health at age 6 years.
This study was performed among 2,045 Dutch children from a population based prospective birth cohort. SCB intake was assessed with a semi-quantitative food frequency questionnaire at the age of 13 months and sex-specific tertiles were created. Children visited the research center at the age of 6 years. We created a continuous cardiometabolic risk factor score including: body fat percentage, blood pressure, insulin, HDL-cholesterol and triglycerides. Age-and sex-specific standard deviation (SD) scores were created for all outcomes. Multivariable linear regression was performed with adjustment for socio-demographic and lifestyle variables of mother and child.
In the total population, we observed an association between higher SCB intake at 13 months of age and a higher cardiometabolic risk factor score at the age of 6 years (0.13SD (95 % CI 0.01; 0.25), highest vs. lowest tertile) After stratification by sex, we found that boys in the highest tertile of SCB intake had a higher cardiometabolic risk factor score (0.18 SD (95 % CI 0.01; 0.34)), as compared to boys in the lowest tertile of SCB intake. There was no significant association in girls. We did not find associations of SCB intake with the individual cardiometabolic risk factors in the total population, or in the stratified analyses.
Higher SCB intake at 1 year of age was associated with a higher cardiometabolic risk factor score at age 6 years in boys, but not in girls. Further research on sex-specific effects of SCBs is needed.
成人饮用含糖饮料（SCB）与代谢综合征风险增加有关。虽然SCB对儿童体重的影响已得到充分证实，但对于幼儿的心脏代谢影响却知之甚少。我们研究了1岁时SCB摄入量与6岁时心脏代谢健康之间的关联。
本研究在来自基于人群的前瞻性出生队列的2045名荷兰儿童中进行。在13个月大时用半定量食物频率问卷评估SCB摄入量，并创建按性别划分的三分位数。儿童在6岁时访问研究中心。我们创建了一个连续的心脏代谢危险因素评分，包括：体脂百分比、血压、胰岛素、高密度脂蛋白胆固醇和甘油三酯。为所有结果创建了按年龄和性别划分的标准差（SD）评分。进行多变量线性回归，并对母婴的社会人口统计学和生活方式变量进行调整。
在总体人群中，我们观察到13个月大时SCB摄入量较高与6岁时较高的心脏代谢危险因素评分之间存在关联（0.13SD（95%CI 0.01；0.25），最高三分位数与最低三分位数相比）。按性别分层后，我们发现SCB摄入量最高三分位数的男孩的心脏代谢危险因素评分高于SCB摄入量最低三分位数的男孩（0.18 SD（95%CI 0.01；0.34））。女孩中没有显著关联。在总体人群或分层分析中，我们未发现SCB摄入量与个体心脏代谢危险因素之间存在关联。
1岁时较高的SCB摄入量与6岁时男孩较高的心脏代谢危险因素评分相关，但与女孩无关。需要进一步研究SCB的性别特异性影响。
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