Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Benef Microbes. 2010 Nov;1(4):327-34. doi: 10.3920/BM2010.0026.
Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.
白细胞介素 (IL)-17 产生的 CD4 T 细胞（'Th17 细胞'）在肠道黏膜中最为丰富，在维持黏膜屏障功能方面发挥着关键作用。最近的研究表明，肠道 Th17 细胞的积累依赖于肠道共生细菌的刺激 - 特别是分段丝状细菌。在这篇综述中，我们总结了我们对小鼠肠道 Th17 合成机制的理解的最新进展，并讨论了它们与感染和炎症性疾病的相关性。
