新型 1,3-二恶烷的合成及生物活性研究作为潜在的抗菌和抗真菌化合物。
Synthesis and biological activity of new 1,3-dioxolanes as potential antibacterial and antifungal compounds.
机构信息
Department of Chemistry, Faculty of Engineering, Istanbul University, 34320 Avcılar, Istanbul, Turkey.
出版信息
Molecules. 2011 Aug 10;16(8):6806-15. doi: 10.3390/molecules16086806.
Abstract
A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.
摘要
通过使用催化量的蒙脱土 K10，使水杨醛与市售二醇反应，以良好的收率和较短的反应时间合成了一系列新的对映体纯和外消旋 1,3-二恶烷 1-8。元素分析和光谱表征确定了所有新合成化合物的结构。测试了这些化合物的可能的抗菌和抗真菌活性。生物筛选表明，除了 1 之外，所有测试的化合物都对 C. albicans 表现出优异的抗真菌活性，而大多数化合物对金黄色葡萄球菌、表皮葡萄球菌、粪肠球菌和铜绿假单胞菌也表现出显著的抗菌活性。
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