Streit Wolfgang J, Xue Qing-Shan
Department of Neuroscience, University of Florida College of Medicine and Evelyn F. McKnight Brain Institute, Gainesville, FL, USA.
Aging Dis. 2010 Dec 1;1(3):254-261.
In this review, we summarize key observations supporting the idea of immunosenescence in the CNS. We provide a discussion of senescent changes that affect microglial cells and emphasize differences between laboratory rodents and humans. Microglial immunosenescence may explain why humans but not rodents develop neurofibrillary degeneration.
在本综述中，我们总结了支持中枢神经系统免疫衰老观点的关键观察结果。我们讨论了影响小胶质细胞的衰老变化，并强调了实验室啮齿动物和人类之间的差异。小胶质细胞免疫衰老可能解释了为什么人类而非啮齿动物会发生神经纤维变性。
