（+）-SCH 351448 的全合成。
Total synthesis of (+)-SCH 351448.
机构信息
Department of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
出版信息
Org Lett. 2011 Sep 2;13(17):4652-5. doi: 10.1021/ol201863b. Epub 2011 Aug 11.
Abstract
A convergent synthesis of (+)-SCH 351448 (1), a monosodium salt of a C(2)-symmetric macrodiolide, is described. Our approach is based on a [4 + 2] annulation with a chiral allyl silane (anti-5c) to assemble the pyran subunits. Homodimerization was carried out in a stepwise fashion; initial esterification at C29' followed by macrocyclization at C29 afforded the desired macrodiolide.
摘要
本文描述了（+）-SCH 351448（1）的一种会聚合成方法，（+）-SCH 351448（1）为 C（2）对称的大环二醇单钠盐。我们的方法基于[4 + 2]环加成反应，使用手性烯丙基硅烷（anti-5c）来组装吡喃亚基。同型二聚体以分步的方式进行；在 C29'处进行初始酯化，然后在 C29 处进行大环化，得到所需的大环二醇。
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