Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33418, USA.
Retina. 2011 Apr;31(4):662-8. doi: 10.1097/IAE.0b013e31821067c4.
To assess the rate of infectious endophthalmitis and to describe the clinical and microbiological features of eyes that develop clinically suspected endophthalmitis after an intravitreal injection of vascular endothelial growth factor antagonists.
The medical records of patients undergoing intravitreal injections of anti-vascular endothelial growth factor agents from January 1, 2005, through December 31, 2010, at a single university referral center and associated satellite clinics were retrospectively analyzed to determine the rate of infectious endophthalmitis after intravitreal anti-vascular endothelial growth factor injections.
Twelve cases (11 patients) of clinically suspected endophthalmitis were identified after a total of 60,322 injections (0.02%; 95% confidence interval, 0.0114%-0.0348%). Of the 12 cases, 11 presented within 3 days of the injection. Of the 7 culture-positive cases, 5 were because of Streptococcus species. In 4 of the 5 Streptococcus cases, final visual acuity was hand motions or worse. The rate of clinically suspected endophthalmitis was 0.018% after bevacizumab and 0.027% after ranibizumab injections.
A very low rate of endophthalmitis after intravitreal injections of anti-vascular endothelial growth factor agents was observed. Patients typically presented within 3 days of injection. Streptococcus species was the most common bacteria isolated, and it was generally associated with poor visual outcomes.
评估感染性眼内炎的发生率，并描述接受血管内皮生长因子拮抗剂玻璃体内注射后发生临床疑似眼内炎的眼部的临床和微生物学特征。
回顾性分析 2005 年 1 月 1 日至 2010 年 12 月 31 日期间在一家大学转诊中心和相关卫星诊所接受血管内皮生长因子拮抗剂玻璃体内注射的患者的病历，以确定血管内皮生长因子拮抗剂玻璃体内注射后感染性眼内炎的发生率。
在总共 60322 次注射（0.02%；95%置信区间，0.0114%-0.0348%）后，发现 12 例（11 例患者）发生临床疑似眼内炎。12 例中，11 例在注射后 3 天内出现。在 7 例培养阳性的病例中，有 5 例是链球菌属。在 5 例链球菌病例中，最终视力为手动或更差。贝伐单抗和雷珠单抗注射后临床疑似眼内炎的发生率分别为 0.018%和 0.027%。
观察到血管内皮生长因子拮抗剂玻璃体内注射后眼内炎的发生率非常低。患者通常在注射后 3 天内出现。链球菌属是最常见的分离菌，通常与视力不良结局相关。
