Megran D W, Lefebvre K, Willetts V, Bowie W R
Department of Medicine, University of Calgary, Alberta, Canada.
Antimicrob Agents Chemother. 1990 Feb;34(2):355-7. doi: 10.1128/AAC.34.2.355.
In this randomized study, a single 800-mg oral dose of cefixime cured 96 of 97 men with uncomplicated gonococcal urethritis, compared with 44 cures of 46 men who received standard therapy with amoxicillin (3 g) plus probenecid (1 g). Both regimens were ineffective against coexistent infection with Chlamydia trachomatis and Ureaplasma urealyticum. Cefixime was well tolerated, and all side effects were mild and self-limited.
在这项随机研究中,单次口服800毫克头孢克肟治愈了97例单纯性淋菌性尿道炎男性患者中的96例,相比之下,接受阿莫西林(3克)加丙磺舒(1克)标准治疗的46例男性患者中有44例治愈。两种治疗方案对沙眼衣原体和解脲脲原体的合并感染均无效。头孢克肟耐受性良好,所有副作用均轻微且为自限性。