Bowie W R, Yu J S, Fawcett A, Jones H D
Br J Vener Dis. 1980 Oct;56(5):332-6. doi: 10.1136/sti.56.5.332.
In a previous study treatment with minocycline 100 mg orally every day for seven days was as effective for nongonococcal urethritis (NGU) as 200 mg for seven days or 100 or 200 mg for 21 days. In this prospective, randomised study men with NGU received tetracycline either 500 mg or 250 mg four times daily for seven days. of 200 men initially enrolled, Chlamydia trachomatis was isolated from 40% and Ureaplasma urealyticum from 48%. Eight of 10 homosexual men compared with 39 (21%) of 190 bisexual or heterosexual men had negative culture results for both C trachomatis and U urealyticum (x2 = 15.5, P < 0.0005). U urealyticum was isolated more frequently from chlamydia-negative men and from men with 10 or fewer sex partners during their lifetime. Both regimens were equally effective in their in-vivo activity against C trachomatis and U urealyticum. Failure rates were similar with the two regimens. More obvious failure with purulent or profuse mucoid discharge and pyuria occurred more frequently with the 250-mg regimen (20% of 76 men on the 250-mg regimen compared with 7% of 67 men on the 500-mg regimen; x2 = 4.45, P < 0.05). Failure occurred more frequently in men who were initially chlamydia-negative and in men in whom U urealyticum persisted after medication. Thus, the 250-mg regimen appeared to be as effective as the 500-mg regimen in the initial treatment of NGU. However, one-third of men had persistent or recurrent urethritis with these regimens, and there is a need for antimicrobial agents with greater in-vivo activity, especially against chlamydia-negative NGU.
在之前的一项研究中，每天口服100毫克米诺环素，连续服用七天，对于非淋菌性尿道炎（NGU）的治疗效果与每天服用200毫克、连续服用七天，或每天服用100毫克或200毫克、连续服用21天的效果相同。在这项前瞻性随机研究中，患有NGU的男性接受四环素治疗，剂量为500毫克或250毫克，每日四次，连续服用七天。在最初纳入的200名男性中，40%的人分离出沙眼衣原体，48%的人分离出解脲脲原体。10名同性恋男性中有8人沙眼衣原体和解脲脲原体培养结果均为阴性，而190名双性恋或异性恋男性中有39人（21%）培养结果为阴性（χ² = 15.5，P < 0.0005）。解脲脲原体在沙眼衣原体阴性的男性以及一生中性伴侣为10个或更少的男性中分离得更为频繁。两种治疗方案在体内对沙眼衣原体和解脲脲原体的活性同样有效。两种方案的失败率相似。250毫克治疗方案中，脓性或大量黏液样分泌物及脓尿导致的更明显失败情况更为频繁（250毫克治疗方案的76名男性中有20%，而500毫克治疗方案的67名男性中有7%；χ² = 4.45，P < 0.05）。最初沙眼衣原体阴性的男性以及用药后解脲脲原体持续存在的男性中失败情况更频繁。因此，250毫克治疗方案在NGU的初始治疗中似乎与500毫克治疗方案一样有效。然而，使用这些方案治疗时，三分之一的男性会出现持续性或复发性尿道炎，因此需要具有更强体内活性的抗菌药物，尤其是针对沙眼衣原体阴性的NGU。
