van Wessem K J P, Meijer J M R, Leenen L P H, van der Worp H B, Moll F L, de Borst G J
Eur J Trauma Emerg Surg. 2011 Apr;37(2):147-54. doi: 10.1007/s00068-010-0032-y. Epub 2010 Jul 13.
The optimal diagnostic strategy for carotid dissection following blunt trauma is yet unclear. The rationale for aggressive screening will be discussed based on a consecutive case series of blunt traumatic carotid artery dissection (CAD).
Five patients admitted to our level I trauma center developed severe complications as a consequence of blunt traumatic CAD. The diagnosis of CAD was delayed in all five patients until serious cerebral ischemia occurred. Despite the current awareness that CAD can result from blunt trauma, this type of injury is often overlooked. Clinical and radiological advances have considerably increased the knowledge of incidence and underlying mechanisms of traumatic CAD. This could have implications for case identification and the evaluation of treatment strategies in clinical trials in the future.
Screening may increase the rate of early CAD diagnosis, but it is unclear if screening will also result in early detection of a treatable lesion. Trials have to provide the answer to whether initiating therapy will lead to improvements in the outcome in traumatic CAD. We therefore believe that screening is a basic condition for initiation of future clinical trials.
钝性创伤后颈动脉夹层的最佳诊断策略尚不清楚。将基于一系列钝性创伤性颈动脉夹层(CAD)的连续病例,讨论积极筛查的基本原理。
5例入住我院一级创伤中心的患者因钝性创伤性CAD出现严重并发症。所有5例患者的CAD诊断均延迟至严重脑缺血发生时。尽管目前已认识到钝性创伤可导致CAD,但这类损伤常被忽视。临床和影像学进展大大增加了对创伤性CAD发病率和潜在机制的认识。这可能对未来临床试验中的病例识别和治疗策略评估产生影响。
筛查可能会提高CAD的早期诊断率,但尚不清楚筛查是否也能早期发现可治疗的病变。试验必须回答启动治疗是否会改善创伤性CAD的预后。因此,我们认为筛查是启动未来临床试验的基本条件。