Biffl Walter L, Egglin Thomas, Benedetto Bernard, Gibbs Frantz, Cioffi William G
Department of Surgery, Rhode Island Hospital/Brown University, Providence, 02903, USA.
J Trauma. 2006 Apr;60(4):745-51; discussion 751-2. doi: 10.1097/01.ta.0000204034.94034.c4.
In light of their potential for devastating consequences, a liberalized screening approach for blunt cerebrovascular injuries (BCVI) is becoming increasingly accepted. The gold standard for diagnosis of BCVI is arteriography (ART), but noninvasive diagnostic alternatives offer clear advantages. Prospective comparative studies found that computed tomographic angiography (CTA) was unreliable in detecting BCVI. However, with advanced CTA technology, it has become more difficult to justify ART in asymptomatic patients. We implemented a liberal screening protocol for BCVI, employing 16-slice CTA. We hypothesized that CTA would detect all clinically significant BCVI.
Patients undergoing computed tomography scanning for cranial or cervical trauma, as well as those with high-risk injury mechanisms or patterns, had craniocervical CTA performed. Abnormal CTA studies were confirmed with ART. Patients were followed for signs or symptoms of ischemic neurologic events.
Over an 11-month period, 331 patients underwent CTA. Eighteen (5.4%) patients had a total of 20 BCVI. There were 11 carotid and 9 vertebral artery injuries. Seven of nine (78%) vertebral injuries were associated with cervical spine fractures. Two patients who did not meet screening criteria had signs or symptoms of BCVI before CTA. No patient with normal CTA developed evidence of BCVI.
CTA detected all clinically significant injuries during this study period. Liberal screening with 16-slice CTA is appropriate and is likely to miss very few significant injuries. A multicenter trial will help to clarify risk factors and the accuracy of noninvasive diagnostic modalities.
鉴于钝性脑血管损伤(BCVI)可能产生毁灭性后果,一种更为宽松的筛查方法正越来越被认可。BCVI诊断的金标准是动脉造影(ART),但非侵入性诊断方法具有明显优势。前瞻性比较研究发现,计算机断层血管造影(CTA)在检测BCVI方面不可靠。然而,随着CTA技术的进步,对于无症状患者采用ART的合理性变得更难论证。我们采用16层CTA实施了一项宽松的BCVI筛查方案。我们假设CTA能够检测出所有具有临床意义的BCVI。
对因颅脑或颈部创伤接受计算机断层扫描的患者,以及具有高风险损伤机制或模式的患者,进行颅颈CTA检查。CTA检查异常的结果通过ART进行确认。对患者进行随访,观察是否出现缺血性神经事件的体征或症状。
在11个月的时间里,331例患者接受了CTA检查。18例(5.4%)患者共有20处BCVI。其中颈动脉损伤11处,椎动脉损伤9处。9处椎动脉损伤中有7处(78%)与颈椎骨折相关。2例不符合筛查标准的患者在CTA检查前出现了BCVI的体征或症状。CTA检查正常的患者均未出现BCVI的证据。
在本研究期间,CTA检测出了所有具有临床意义的损伤。采用16层CTA进行宽松筛查是合适的,且很可能极少遗漏重大损伤。一项多中心试验将有助于明确危险因素以及非侵入性诊断方法的准确性。