Nevins Myron, Nevins Marc L, Kim Soo-Woo, Schupbach Peter, Kim David M
Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA.
Int J Periodontics Restorative Dent. 2011 Jul-Aug;31(4):367-73.
This prospective split-mouth pilot case series compared the use of a bilayer collagen matrix (CM) to an autogenous gingival graft (AGG) in the ability to increase the zone of keratinized attached gingiva. Five patients with inadequate amounts of keratinized attached gingiva bilaterally in the posterior mandible were enrolled using a split-mouth design. There were statistically significant increases in attached gingiva at all test (CM) and control (AGG) sites. The CM sites at 12 months blended well with surrounding tissues, while the AGG sites were morphologically dissimilar to the adjacent areas. Biopsy results showed intrapatient histologic similarity between CM and AGG treatments, with all sites exhibiting mature connective tissue covered by keratinized epithelium. Thus, the obtained data support further investigations in evaluating the role of CM as a viable alternative to AGG in augmenting areas deficient in keratinized gingiva.
本前瞻性裂口式病例系列研究比较了双层胶原基质（CM）与自体牙龈移植（AGG）在增加角化附着龈区域方面的能力。采用裂口式设计纳入了5例双侧下颌后部角化附着龈量不足的患者。所有试验（CM）部位和对照（AGG）部位的附着龈均有统计学意义的增加。12个月时CM部位与周围组织融合良好，而AGG部位在形态上与相邻区域不同。活检结果显示CM和AGG治疗在患者内部组织学相似，所有部位均表现为角化上皮覆盖的成熟结缔组织。因此，所获得的数据支持进一步研究以评估CM作为AGG的可行替代物在增加角化龈缺乏区域方面的作用。
