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一项关于使用两种钛网覆盖的无机牛骨材料对种植体周围裂开性缺损进行引导骨再生的随机对照试验。

A Randomized Controlled Trial of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with Two Anorganic Bovine Bone Materials Covered by Titanium Meshes.

作者信息

Lim JaeHyung, Jun Sang Ho, Tallarico Marco, Park Jun-Beom, Park Dae-Ho, Hwang Kyung-Gyun, Park Chang-Joo

机构信息

Department of Oral and Maxillofacial Surgery, Korea University Ansan Hospital, Ansan-si 15355, Korea.

Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, Seoul 02841, Korea.

出版信息

Materials (Basel). 2022 Aug 1;15(15):5294. doi: 10.3390/ma15155294.

Abstract

The aim of this study is to compare two low-temperature sintered anorganic bovine bone materials (ABBMs), Bio-Oss (Geistlich, Wolhusen, Switzerland) and A-Oss (Osstem, Seoul, Korea), for GBR in dehiscence defects. A single implant was placed simultaneously with GBR in the buccal or bucco-proximal osseous defect by double-layering of inner allograft and outer ABBM, covered by a preformed ultrafine titanium mesh and an absorbable collagen membrane. Grafted volume changes were evaluated by cone-beam computed tomography, taken preoperatively (T0), immediately after implant surgery (T1), after re-entry surgery (T2), and after delivery of the final restoration (T3). The density of the regenerated bone was assessed by measuring the probing depth on the buccal mid-center of the mesh after removing the mesh at T2. Postoperative sequelae were also recorded. Grafted volume shrinkage of 46.0% (0.78 ± 0.37 cc) and 40.8% (0.79 ± 0.33 cc) in the Bio-Oss group (8 patients) and A-Oss group (8 patients), respectively, was observed at T3 (p < 0.001). There were no significant differences in grafted volume changes according to time periods or bone density between the two groups. Despite postoperative mesh exposure (3 patients), premature removal of these exposed meshes and additional grafting was not necessary, and all implants were functional over the 1-year follow-up period. Both ABBMs with titanium meshes showed no significant difference in the quantity and density of the regenerated bone after GBR for peri-implant defects.

摘要

本研究的目的是比较两种低温烧结的无机牛骨材料(ABBMs),即Bio-Oss(盖氏公司,瑞士沃尔胡森)和A-Oss(奥齿泰公司,韩国首尔),用于根面缺损引导骨再生(GBR)的效果。通过双层植入同种异体骨和外层ABBM,在颊侧或颊近中骨缺损处同时进行GBR并植入单个种植体,覆盖预先成型的超细钛网和可吸收胶原膜。通过术前(T0)、种植手术后即刻(T1)、再次手术时(T2)以及最终修复体戴入后(T3)的锥形束计算机断层扫描评估移植骨体积变化。在T2时移除钛网后,通过测量网片颊侧中央的探诊深度评估再生骨的密度。同时记录术后后遗症。在T3时,Bio-Oss组(8例患者)和A-Oss组(8例患者)的移植骨体积分别收缩了46.0%(0.78±0.37 cc)和40.8%(0.79±0.33 cc)(p<0.001)。两组之间在不同时间段的移植骨体积变化或骨密度方面无显著差异。尽管术后有3例患者出现钛网暴露,但无需过早移除这些暴露的钛网并进行额外植骨,且在1年的随访期内所有种植体均功能良好。两种带有钛网的ABBMs在种植体周围缺损GBR后再生骨的数量和密度方面均无显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7a4/9369984/64d8cef295d6/materials-15-05294-g001.jpg

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