Petersen P, Kastrup J, Helweg-Larsen S, Boysen G, Godtfredsen J
Department of Neurology, University Hospital, Copenhagen, Denmark.
Arch Intern Med. 1990 Apr;150(4):819-21.
As previously reported, 1007 patients with chronic atrial fibrillation participated in the Copenhagen AFASAK study. Before inclusion to trial, they all had a physical examination, chest roentgenogram, and echocardiogram with determination of left atrial size. This study evaluated the importance of cardiovascular risk factors for development of thromboembolic complications. To exclude any treatment effects on occurrence of thromboembolic complications, we included only the 336 patients from the placebo group. Using Cox's regression model, previous myocardial infarction was a significant risk factor for development of thromboembolic complications. Age, gender, heart failure, chest pain, hypertensive heart disease, diabetes, systolic and diastolic blood pressure, smoking, relative heart volume, and left atrial size were all without statistical importance.
如先前报道，1007例慢性房颤患者参与了哥本哈根AFASAK研究。在纳入试验前，他们均接受了体格检查、胸部X线检查以及测定左心房大小的超声心动图检查。本研究评估了心血管危险因素对血栓栓塞并发症发生的重要性。为排除任何治疗对血栓栓塞并发症发生的影响，我们仅纳入了安慰剂组的336例患者。使用Cox回归模型，既往心肌梗死是血栓栓塞并发症发生的显著危险因素。年龄、性别、心力衰竭、胸痛、高血压性心脏病、糖尿病、收缩压和舒张压、吸烟、相对心脏容积以及左心房大小均无统计学意义。
