Hamuro J, Röllinghoff M, Wagner H, Seitz M, Grimm W, Gemsa D
Z Immunitatsforsch Immunobiol. 1979 Feb;155(3):248-54.
PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two beta (1-3) glucans, the antitumor active lentinan and the inactive pachyman, 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.
在给小鼠注射两种β(1-3)葡聚糖（抗肿瘤活性的香菇多糖和无活性的茯苓聚糖）后，研究了腹膜渗出细胞中前列腺素E（PGE）和前列腺素F（PGF）的释放情况。在注射这两种多糖4天后，自发的以及吞噬作用诱导的PGE和PGF释放均受到显著抑制。然而，只有免疫增强剂香菇多糖诱导的腹膜渗出细胞表现出PG释放的持续时间更长的减少。数据表明，T细胞佐剂香菇多糖可能通过减少腹膜渗出细胞中免疫抑制性前列腺素的合成来增强细胞免疫反应。
