Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
J Perinat Med. 2011 Nov;39(6):731-6. doi: 10.1515/jpm.2011.078. Epub 2011 Aug 13.
To determine whether neonatal intensive care unit (NICU) admission hypothermia is associated with an intrauterine inflammatory response.
We analyzed a cohort of 309 very low birthweight infants to determine relationships between admission hypothermia, chorioamnionitis, and serum and cerebrospinal fluid (CSF) interleukin (IL)-1β, IL-6, and tumor necrosis factor-α.
Admission hypothermia <36°C occurred in 72% of patients <26 weeks and 44% of patients ≥26 weeks gestational age. NICU admission hypothermia was not associated with histologic chorioamnionitis or with elevated serum cytokine concentrations. CSF IL-6 concentrations ≥6.3 pg/mL were associated with admission hypothermia in infants <26 weeks' gestation. Clinical chorioamnionitis was associated with a lower risk of admission hypothermia, while cesarean section delivery was associated with increased risk.
NICU admission hypothermia is common among preterm infants and is not associated with the fetal inflammatory response syndrome. Hypothermia is less common in the setting of clinical chorioamnionitis and more common in cesarean section deliveries, identifying two groups in whom extra attention to appropriate thermoregulation is warranted.
确定新生儿重症监护病房（NICU）入院低体温是否与宫内炎症反应有关。
我们分析了 309 名极低出生体重儿的队列，以确定入院低体温、绒毛膜羊膜炎以及血清和脑脊液（CSF）白细胞介素（IL）-1β、IL-6 和肿瘤坏死因子-α之间的关系。
入院时体温<36°C 发生在<26 周的 72%和≥26 周的 44%患者中。NICU 入院低体温与组织学绒毛膜羊膜炎或血清细胞因子浓度升高无关。CSF IL-6 浓度≥6.3 pg/mL 与<26 周胎龄的入院低体温相关。临床绒毛膜羊膜炎与入院低体温的风险降低相关，而剖宫产与风险增加相关。
NICU 入院低体温在早产儿中很常见，与胎儿炎症反应综合征无关。在临床绒毛膜羊膜炎的情况下，低体温较少见，而在剖宫产中，低体温较常见，这表明在这两组人群中需要特别注意适当的体温调节。
