Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, Louisville, KY 40222, USA.
Virol J. 2011 Aug 12;8:399. doi: 10.1186/1743-422X-8-399.
Longitudinal mark-recapture studies of rodents in two sites in the Mbaracayú Biosphere Reserve in the Interior Atlantic Forest of eastern Paraguay have revealed a complex and intriguing pattern of hantaviruses harbored by rodents in this area. Full-length sequencing and phylogenetic analyses were conducted for several rodents from Akodon montensis and Oligoryzomys fornesi. The phylogenetic relationships of these viruses were analyzed in the context of hantaviruses in South America with published S- and M-segment sequences.
Phylogenetic analyses of hantaviruses identified in the Mbaracayú Biosphere Reserve in Paraguay revealed Jabora and Juquitiba viruses are harbored by Akodon montensis and Oligoryzomys fornesi, respectively. These analyses revealed that in general the constituents of the major subclade for the S- and M-segments differ for the South American hantaviruses. Further, the two major groups within subclade C for the M-segment reflect in general the lethality associated with the viruses within each group.
Phylogenetic studies of Jabora and Juquitiba viruses and other Paraguayan viruses in the context of American hantaviruses revealed reassortment and host-switching in the evolution of South American hantaviruses.
在巴拉圭东部大西洋内陆森林的 Mbaracayú 生物圈保护区的两个地点对啮齿动物进行的纵向标记重捕研究揭示了该地区啮齿动物携带的汉坦病毒的复杂而有趣的模式。对来自 Akodon montensis 和 Oligoryzomys fornesi 的几种啮齿动物进行了全长测序和系统发育分析。这些病毒的系统发育关系在南美的汉坦病毒以及已发表的 S-和 M-节序列的背景下进行了分析。
在巴拉圭 Mbaracayú 生物圈保护区鉴定的汉坦病毒的系统发育分析表明，Jabora 和 Juquitiba 病毒分别由 Akodon montensis 和 Oligoryzomys fornesi 携带。这些分析表明，总体而言，南美的汉坦病毒的 S-和 M-节的主要亚分支组成不同。此外，M-节亚分支 C 内的两个主要组通常反映了与每组内病毒相关的致死率。
在美洲汉坦病毒的背景下对 Jabora 和 Juquitiba 病毒以及其他巴拉圭病毒的系统发育研究表明，在南美的汉坦病毒进化过程中发生了重组和宿主转换。
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